You can see my thread here on PR when I started Rituxan on Dec 18, 2017. Today is June 5, 2018; so it's coming up on 6 months. Very little change to my well-being, strength. Have had 3 infusions. However, one big change is I'm sick constantly. I began to get sick mid-March. Cough, yellow mucus, increased fatigue, sneeze, stuffy nose. It started going away by mid April. Then I had infusion 3. Shortly thereafter it came back. May 7'ish I began taking Augmentin antibiotics. It went away by May 24. Now it's back- starting May 30 to now (June 5). Prior to rifaximin, and for the last 3 years before it with chronic fatigue, i never got sick. This could be because my immune system was on overdrive (and the reason they thought rituxan would help as it would suppress the overactive immune system). Since taking Ritux, I am now sick constantly. I have to say I am not certain they are related, but it seems awfully coincidental. There have been some changes to my sleep patterns and exposures to water in my apartment, which be a factor. However, I find it a little odd that so far my Dr. at Center for Complex Diseases has seemed to imply that Rituxan would not increase my susceptibility or reduce my body's ability to fight these colds//infections. Anyone got any ideas? 6 months ago was so hopeful Rituxan would turn things around. I realize there's still some time to see if it would work but bummed I'm at where I'm at. The infections and symptoms esp the increased fatigue fighting them off don't help.