According to Andy Cutler (and both common sense wise and from hard experience I think he is right) if you don't take chelators (like ALA) on their half life, the metals will redistribute and not come out. The redistribution will make you worse. That's why I have a warning in red at the top of my blog page (linked in my signature link) NOT to take the ALA recommended on Freddd's protocol (unless you're doing Cutler's protocol). The issue (according to Cutler) with NAC can be problems tolerating the thiols. If that's the case, you can do glutamine and glycine which are precursors to NAC. Then NAC is a precursor to glutathione. I think coffee enemas are supposed to increase glutathione somehow. I'm not sure of the mechanism off hand. Cutler didn't recommend them, I think because of the yuck factor, but some people really like them and get benefit from them. Another option is vitamin C which is a co-factor for glutathione recycling. That works for me - I can tell that my chemical sensitivities are a lot better when I take vitamin C. Hmmmm, I just read the article you linked to and it sounds like large amounts of NAC could cause redistribution too. So it sounds like you've been tolerating coffee enemas, so that sounds ok. I wouldn't suggest taking ALA. It sounds like if you do want to take NAC to keep the dose low. If you're feeling worse, of course, discontinue, and maybe try glutamine and glycine instead. I read the other article on NAC and bacteria. It sounds like the benefit is actually coming from the production of glutathione. So you have several options to make glutathione. I think I would do them on different days and maybe wait a few days in between just to be on the safe side. Then it's easier to tell what is doing what. Keep good notes on how you feel afterwards - it can really help sort things out as to what you tolerate and what's helping or not. You probably won't remember if you don't write it down. Then if you want to combine some of them, start with low doses and gradually work up to larger doses as tolerated.