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Purinergic Signalling and Thyroid

Discussion in 'General ME/CFS Discussion' started by debored13, Aug 11, 2018.

  1. debored13

    debored13 Senior Member

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    Vermont, school in Western MA
    Given that Naviaux has been talking about CFS as hypometabolism, and has been doing some of the most robust research on CFS, I wonder if anybody has tried to find the links between his model of purinergic signalling being disrupted, and thyroid issues. Also curious about how these two connect to mast cells. I haven't had the energy to look into this stuff for awhile but I think it's possibly a promising area. Dumping some links in case anybody is curious/wants to follow up.

    the leading theory on cfs/me now is by robert naviaux. IT's an idea that CFS is an illness state caused by an initial response to a pathogen causing purinergic signalling to be switched on, and never get switched off.http://www.pnas.org/content/113/37/E5472

    I've started to find a little evidence for purinergic signalling crossing over with thyroid issues, which is not surprising, as purinergic signalling is very important for intracellular signalling across a number of physiological systems

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944044/

    search and you may find more... i'm very tired

    https://www.hindawi.com/journals/jtr/2013/434727/
     
  2. wigglethemouse

    wigglethemouse Senior Member

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    I thought this Aug 3 paper was a good read. It ties a lot of the research together in one place and hypothesizes that Mast Cells are activated in the brain by CRH.
    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?
    http://jpet.aspetjournals.org/content/jpet/early/2018/08/03/jpet.118.250845.full.pdf
    And this is the third paper I've read lately talking about CRH activating mast cells. CRH is at the heart of the Cortene hypothesis.
     
  3. Wishful

    Wishful Senior Member

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    Whenever I read papers such as this, about ME/CFS metabolics, I wonder whether their patient samples were only from the sub-group of those with physical limitations. If so, then the findings are about a common symptom, not necessarily the core cause.
     
    wigglethemouse likes this.

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