frozenborderline
Senior Member
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Given that Naviaux has been talking about CFS as hypometabolism, and has been doing some of the most robust research on CFS, I wonder if anybody has tried to find the links between his model of purinergic signalling being disrupted, and thyroid issues. Also curious about how these two connect to mast cells. I haven't had the energy to look into this stuff for awhile but I think it's possibly a promising area. Dumping some links in case anybody is curious/wants to follow up.
the leading theory on cfs/me now is by robert naviaux. IT's an idea that CFS is an illness state caused by an initial response to a pathogen causing purinergic signalling to be switched on, and never get switched off.http://www.pnas.org/content/113/37/E5472
I've started to find a little evidence for purinergic signalling crossing over with thyroid issues, which is not surprising, as purinergic signalling is very important for intracellular signalling across a number of physiological systems
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944044/
search and you may find more... i'm very tired
https://www.hindawi.com/journals/jtr/2013/434727/
the leading theory on cfs/me now is by robert naviaux. IT's an idea that CFS is an illness state caused by an initial response to a pathogen causing purinergic signalling to be switched on, and never get switched off.http://www.pnas.org/content/113/37/E5472
I've started to find a little evidence for purinergic signalling crossing over with thyroid issues, which is not surprising, as purinergic signalling is very important for intracellular signalling across a number of physiological systems
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944044/
search and you may find more... i'm very tired
https://www.hindawi.com/journals/jtr/2013/434727/