Hi everyone, One of my PEM symptoms is nasal/sinus infection. A few weeks ago I saw an ENT specialist and he confirmed a staph infection. This is the same infection I keep getting in the same spot all the years I have had ME. It sometimes get a very sore throat and intense heat with it. I am now treating it with saline nasal washes which is helping. Not completely gone yet, but hoping it will settle right down again soon. I wonder how many other MEs get the nasal/sinus induced infection with PEM. Do you get the staph infections also? I can't work out what it is about PEM that does this. Obviously there is immune system involvement in some of the ME pathway? Or is there another process that can cause this immune-like behaviour?