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This discussion refers to hypermethylation brought on by too many methyl donors. For me, thanks to MTHFR, COMT & CBS issues, too many methyl donors, like folate, cause me to experience the following: increased heat/ hot flashes, headache, tinnitus, body aches, insomnia, and something else I'm forgetting. Many people experience a lot of anxiety when having a hypermethylation episode. It's a miserable, immediate form of inflammation. And, yes, this is the overmethylation that Ben Lynch discusses.
I'm so sensitive to methyl donors that I do not take any form of folate as a supplement, nor TMG, not Folinic Acid. I often have hypermethylation episodes after eating too much folate rich food - like salads.
I totally understand your question as the word overmethylation is used by different factions...
Hi Carnation4000. I'm new here...although I've lurked in the background for a long time as a very interested party. I am struggling with similar problems as you...MTHFR, COMT, CBS, overmethylation, weight gain that won't budge, inflammation, and the symptoms you listed above. I wanted to reply because the above symptoms sound like salicylate sensitivity to me (inc loss of memory!). Since I'm new here I don't know if this is a hot topic...or not on the radar. I discovered that I had a very severe case of sal poisoning 1.5 years ago...and it's made a HUGE difference for me getting off Mediterranean foods. I will gladly share more information if it would be helpful to you.