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(Ongoing study) "Infectious Triggers of Chronic Fatigue Syndrome"

Discussion in 'Latest ME/CFS Research' started by leelaplay, May 22, 2010.

  1. leelaplay

    leelaplay member

    Tom Kindlon to CO-CURE Apr 26

    [sb: I hadn't seen this before and found nothing in advanced search. Is this related to the spinal tap study Cort participated in and wrote about? I don't see XMRV or retrovirus in the project terms, but the funding started this March.

    Does anyone know anything more?] i.e.

    Project Number: 1R21AI088765-01

    Contact Principal Investigator: SCHUTZER, STEVEN E



    Abstract Text:

    DESCRIPTION (provided by applicant): chronic fatigue syndrome (CFS) is a
    major disabling illness of unknown etiology. It directly impacts more than
    four million Americans. Infectious agents have been highly suspected but
    none have ever been validated. Obstacles to their discovery have been lack
    of a broad approach that can both detect the presence of multiple microbes
    in a single sample and detect novel or variants of microbes. This has been
    further hampered because more than 99% of all microbes cannot be cultured
    and may go undetected.

    In contrast to past limitations, we will use a new
    approach that can surmount these obstacles. The discovery of potential
    pathogens in cerebrospinal fluid
    of CFS would be field-altering in terms of
    approach to the study of the disease and possible early detection,
    prevention and treatment. This could be the gateway step to generate new
    hypotheses and begin investigation into a microbe's causal association and
    ways to prevent (egg vaccine) or counteract the effects of a microbial

    PUBLIC HEALTH RELEVANCE: chronic fatigue syndrome is the major acquired
    disease of productive adults. The cause remains unknown. If we can uncover
    an infectious cause, which is suspected, diagnostics and therapies may be
    developed to decrease costs and suffering to the individual and the burden
    on our health care system and economy.

    Public Health Relevance Statement:
    Project Narrative chronic fatigue syndrome is the major acquired disease of
    productive adults. The cause remains unknown. If we can uncover an
    infectious cause, which is suspected, diagnostics and therapies may be
    developed to decrease costs and suffering to the individual and the burden
    on our health care system and economy.

    Project Terms:
    21+ years old; Adult; Agreement; American; Antiviral Therapy; Arthralgia;
    Bacteria; Blood; Brain; CF patients; Causality; Cell Communication and
    Signaling; Cell Signaling; Central Nervous System; Cerebrospinal Fluid;
    Cerebrum; chronic fatigue Disorder; chronic fatigue syndrome; chronic
    fatigue and Immune Dysfunction syndrome; chronic fatigue-Fibromyalgia
    syndrome; Cognitive Disturbance; Cognitive Impairment; Cognitive decline;
    Cognitive function abnormal; Data; Detection; Diagnosis; Diagnostic;
    Disease; Disorder; Disturbance in cognition; Dysfunction; Early Diagnosis;
    Encephalomyelitis, Myalgic; Encephalon; Encephalons; Etiology; Exclusion;
    Exertion; fatigue; Freezing; Functional disorder; Genetic; Grippe;
    Healthcare Systems; Human, Adult; Impaired cognition; Individual; Infectious
    Agent; Infectious Mononucleosis-Like syndrome, chronic; Influenza;
    Intracellular Communication and Signaling; Investigation; Investigators;
    Joint Pain; Knee; Knowledge; Lack of Energy; Liquid substance; Lumbar
    Puncture; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging;
    Magnetic Resonance Imaging Scan; Medical; Medical Imaging, Magnetic
    Resonance / Nuclear Magnetic Resonance; Method LOINC Axis 6; Methodology;
    Methods; Microbe; Muscle; Muscle Tissue; NMR Imaging; NMR Tomography;
    Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurologic;
    Neurological; Nuclear Magnetic Resonance Imaging; Nucleic Acids; Onset of
    illness; Operation; Operative Procedures; Operative Surgical Procedures;
    Patient Self-Report; Patients; Physiopathology; Postviral fatigue syndrome;
    Prevention; Protozoa; Protozoal; Publishing; Reporting; Research Personnel;
    Researchers; Reticuloendothelial System, Blood; Royal Free Disease;
    Sampling; Self-Report; Signal Transduction; Signal Transduction Systems;
    Signaling; Sleep disturbances; Spinal Anesthesia; Spinal Puncture; Surgical;
    Surgical Interventions; Surgical Procedure; Symptoms; syndrome; Systems,
    Health Care; Testing; Vaccines; Variant; Variation; Virus; Viruses, General;
    Zeugmatography; adult human (21+); base; biodefense; biological signal
    transduction; cognitive dysfunction; cognitive loss; cognitively impaired;
    cost; cystic fibrosis patients; design; designing; disease causation;
    disease etiology; disease onset; disease/disorder; disease/disorder
    etiology; disorder etiology; disorder onset; early detection; egg;
    experience; flu infection; fluid; fungus; improved; infectious organism;
    influenza infection; liquid; microbial; new approaches; novel; novel
    approaches; novel strategies; novel strategy; pathogen; pathophysiology;
    patients with CF; patients with cystic fibrosis; platform-independent;
    prevent; preventing; public health relevance; spinal block; spinal fluid;
    surgery; treatment of viral infectious disease

    Other Information:
    RFA/PA: PA-09-164
    DUNS Number: 623946217
    CFDA Code: 855
    Study Section:
    ZRG1 Project Start Date: 1-MAR-2010
    Project End Date: 29-FEB-2012

    Fiscal Year: 2010
    Budget Start Date: 1-MAR-2010
    Budget End Date: 28-FEB-2011

    Administering Institutes or Centers: NATIONAL INSTITUTE OF ALLERGY AND

    Project Funding Information for 2010: Total Funding: $273,000

    Year Funding IC FY Total Cost by IC
  2. Hope123

    Hope123 Senior Member

    Sounds like Dr. Shutzer got funding from NAIAD......which is good. A good person to ask about this Tomk is Dr. Ken Friedman or Marley Silverman as they both have ties to the medical school in New Jersey.

    I believe the study Cort was involved in regarded proteomics and not infectious agents directly and involved another group at Georgetown U headed by Baraniuk.
  3. ixchelkali

    ixchelkali Senior Member

    Long Beach, CA
    Googling Dr Shutzer, it looks like he's done some interesting research on Lyme.
  4. leelaplay

    leelaplay member

    thanks for the info Hope123 and ixchelkali.

    I'll be interested to hear more about this study. Maybe I'll email them and ask if they are also looking into XMRV now. I'm sure they know that WPI has offered to share samples, and the NIH now has true positives and negatives available for all. The Germans found it in the respiratory tract. WPI in blood and cells (????? so embarassing to display my ignorance after 7 1/2 months of trying to read the science).

    Hope - while tomk posted the info to co-cure, I copied from co-cure onto the forums here, and they are my, [sb:'s] comments and question at the top.
  5. Dolphin

    Dolphin Senior Member

    In the Nakamura et al. (2010) study, more testing was possibly because of a non-profit:
  6. Enid

    Enid Senior Member

    What an interesting approach. Always felt (unable to converse at the time) pathogen(s) should have been discovered at lumbar puncture stage. My onset - Vertigos and limited thinking capacity amongst others, and a pressure in the spinal column just like the one left by a Myelogram 20 years previously. This was confirmed when requested hastily to stop bearing down when the original request to do so had passed me by. All ME nasties followed.

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