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Old post on immune abnormalities in xmrv +

Discussion in 'XMRV Testing, Treatment and Transmission' started by heapsreal, May 13, 2011.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

    australia (brisbane)
    Theres an old post on immune abnormalities in xmrv positive patients and a study suggesting elevated cd8 lymphocytes and poor nk dysfunction are common in xmrv. At the moment funds stop me from getting tested for xmrv but others who have tested positive to xmrv, have they also had testing showing elevated cd8 lymphocytes and poor nk function??? ,this study appears to have come from Italy, so xmrv is being found in other countries just not common knowledge.

    appreciate anyones advice or experience with this.

  2. Forebearance

    Forebearance Senior Member

    Great Plains, US
    I haven't had cd8 tested, but I am XMRV+ and tested low in NK cell function.
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

    australia (brisbane)
    interesting. It would be interesting to know what other immune abnormalities xmrv+ have eg neutropenia etc

  4. Rrrr

    Rrrr Senior Member

    this is from an old post. i'm re-posting here, now:

    Treating cytokine up/down-regulation

    WPI & NCI Paper

    "Type 1 IFN Pathyway Response to Viral Infection in Chronic Fatigue Syndrome"

    Mikovits,J. Hagen,K. Peterson,D. Stephens,R. Lombardi,V.
    Whittemore Peterson Institute, Reno, NV, USA. Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, MD, USA.

    118 CFS patients
    138 Controls



    IL-8: 1045
    MIP-1a: 763
    MIP-1b: 1985
    IL-6: 336
    TNF-a: 148
    IL-1b: 500
    IP-10: 98
    IFN-a: 35
    IL-13: 28
    IL-7 160


    IL-8: 13
    MIP-1a: 91
    MIP-1b: 164
    IL-6: 29
    TNF-a: 13
    IL-1b: 56
    IP-10: 32
    IFN-a: 60
    IL-13: 86
    IL-7: 60

    Guide to Chemokines/Cytokines:

    IL-8: RNase L & CMV activated
    MIP-1a: Elevated in neurodegenerative disease
    MIP-1b: Elevated in neurodegenerative disease
    IL-6: Stimulates chronic inflammation
    TNF-a: Stimulates chronic inflammation
    IL-1b: Stimulates chronic inflammation
    IP-10: Interferon response protein
    IFN-a:Stimulates macrophages and NK cells to elicit an anti viral response
    IL-13: Inhibits inflammatory cytokine production
    IL-7: Stimulates proliferation of B & T lymphocytes & NK cells

    Summary and conclusions:

    Cytokine and Chemokine profiling in combination with machine logic algorythms reveals an inflammatory signature consistent with an over-expression of herpes virus and is useful for diagnosis for CFS

    more info on cytokine and chemokines (posts #401 and those after it)

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