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NutrEval Results, any help?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by lolasana, Feb 7, 2012.

  1. lolasana


    Bay Area, CA
    Hi all,

    I got my NutrEval results back. My doctor, who is an integrative MD but not a CFS specialist, went over the results with me. She is mostly concerned about the low glutathione (for which she is recommending NAC) and the high mercury (though I have never had any amalgams, the mercury must be from fish which I eat 3-6x/week).

    I know that there are probably some other nuggets in there, but my doctor might not be specialized enough to interpret this completely. I'm attaching the results here in case anyone has any insight. So any help from anyone out there would be greatly appreciated.


    Attached Files:

    Gloria H likes this.
  2. lolasana


    Bay Area, CA
    NutrEval interpretation based on my research

    I know people frequently come to these forums trying to interpret their own results. I've been doing a lot of research: medical journals, the book Laboratory Evaluations for Integrative and Functional Medicine, my own physician, and scavenging the interpretations of other's results.

    That said, these are just my best guesses based on my own research. I am far far from knowledgeable in this area.

    Here is my understanding of some of the NutrEval results (I focused on my own results that were abnormal, so this isn't comprehensive):

    Pyruvic acid (pyruvate): elevated in thiamin deficiency

    Citric acid (and its intermediates): can be low due to biosythesis, such as heme synthesis

    Succinic acid: decreased in deficiency of B12, leucine, and/or isoleucine

    Vanilmendalic acid: if low, suggests low levels of norepinephrine. Could be due to tyrosine deficiency.

    Homovanillic acid: if low, suggests low levels of dopamine. Could be due to tyrosine deficiency.

    5-OH-indoleacetic: Increased when taking SSRIs. Can lead to low tryptophan.

    alpha-ketoadipic acid: Elevation means B vitamin or lipoic acid deficiency.

    FIGlu: High FIGlu indicates partial methylation block

    Methylmalonic acid: elevation indicates partial methylation block

    3-Hydroxyisovaleric acid: elevation in biotin deficiency

    Pyroglutamic acid: Low level indicates low glutathione in the intestines

    Lysine: low levels linked w/anemia. Essential amino acid needed for B6 activation

    Taurine: can be elevated due to dietary intake of fish, liver/organ meats, taurine-supplemented foods. Also elevated in zinc deficiency.

    Alanine: Low levels can cause exercise fatigue and hypoglycemia.

    Aspartic Acid: B6 deficiency can cause Aspartic Acid to rise and not be fed into the citric acid cycle, which means Citric acid, Cis-Acitonic, and Isocitric will all be reduced.

    Cystine: Low cystine coupled w/low glutamine is a sign of muscle catabolism (ie. body burning muscle for fuel)

    Glycine: low glycine indicates low glutathione

    Ethanolamine: Needed for choline formation. Can be obtained from dietary lecithin.

    Sarcosine: Elevated when FIGlu is elevated; indicates folate metabolism impairment.

    1-Methylhistidine: Can be elevated from high intake of chicken, turkey, salmon, tuna.

    Beta-Alanine: High levels indicate breakdown of "unwanted" body tissues. Can impair body's use of Taurine.

    Glutamine/Glutamate: low ratio indicates deficiency of B vitamins

    Oleic acid: Need B vitamins, C, zinc, and magnesium to increase.

    Tricosanoic acid: increased levels indicate need for increased biotin or B12 in order to convert to burnable short-chain fatty acids. Can also indicate a diet high in soluble fiber.

    Dihomo-y-linoleic acid: low levels can be improved through use of black currant oil, borage oil, or evening primrose oil to increase GLA levels

    Mercury: RBC mercury is best for determining levels of methylmercury and can be influenced greatly by eating fish

    So now the question is: what do I do about all of this? Well, I plan to continue supplementing with the active B vitamins, add alpha lipoic acid, black currant oil, branched chain amino acids, L-glutamine, and L-glycine. My doctor also really wants me to supplement with NAC to try to increase cystine levels, so I will give that a go (I know there are mixed opinions on NAC supplementation).

    Anyway, I hope this might be of help to other people struggling with their own NutrEval results in the future.
    SaraM likes this.
  3. Rosebud Dairy

    Rosebud Dairy Senior Member

    thank you!

    cool stuff
  4. lolasana


    Bay Area, CA
    I wanted to add that even though the NutrEval supplement suggestions suggested that I supplement with L-glutamine at 1g/day, I have decided upon further research not to take this advice. My glutamate (glutamic acid) levels are already high. Since glutamine can become glutamate, it is apparently a bad idea to supplement if glutamine if glutamate levels are high.

    I'm planning to stick with the B vitamins and begin ALA, branched chain amino acids, and black currant oil but not other amino acids.

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