Hi all, I've never been diagnosed with CFS but I have been suffering from fatigue for several years that will not respond to various therapies. I came across this board after my holistic MD recommended I start taking active B vitamins because she feels that my body is not detoxifying itself correctly. She also ordered a NutrEval test, but I am still waiting on the results. Here are the symptoms that I've had for the last 2-3 years: Fatigue (it's not debilitating as I can still work and do yoga, but I feel tired throughout the day and can no longer tolerate strenuous exercise, though I was quite athletic 3 years ago) Low RBC: my count is usually around 3.8 (normal is 4.0-5.1) and my MCV is usually between 95-98. This does not respond to iron therapy, part of the reason my MD suggested the active Bs High estrogen levels that cause ovarian cysts, PMS, and other symptoms. This has been confirmed several times by blood and urine tests. Water retention: can be fixed with rx diuretics, but the diuretics make my blood pressure too low and I get heart palpitations and feel like I'm going to pass out if I take them, so I just deal with the edema (which is on the order of 10-15 pounds) High heart rate that spikes quickly with exertion Low thyroid function (confirmed by TSH, Free T4, and Free T3 tests) but no auto-immune thyroid disease (no antibodies, all types tested several different times) Poor sleep: I only sleep deeply with the help of 2mg of melatonin each night Vascular issues? I have developed little red spots, like petechiae or angiomas all over my body Odd chemical or nutrient intolerances: can't drink any caffeine without feeling terrible, can't take anything with more than about 100mcg of iodine or my salivary glands swell up My diet is quite good; I eat Paleo but with fermented dairy. I have to eat a lower fat, higher protein, higher carb (fruits and starchy veg) Paleo in order to feel good. My digestion since eating this way has been great. I'm hoping the active B vitamins will help me. Two weeks ago, I started taking the 5mg Jarrow B12; this actually increased my fatigue and made me very sleepy in the afternoon. One week ago I added the 10mg Source Naturals dibencozide. Almost immediately, my mental energy increased significantly. My memory improved, word recall improved, my mood improved, it's great! But so far, no physical effects, just mental. Yesterday I started taking the Pure Encapsulations 950 multi (w/o iodine) which contains 800mcg Metafolin and 25mg P-5-P. So we'll see what that does. I take a slew of other supplements, but I don't think they should negatively impact the active B regimin. But just in case, here is the long list: Fish Oil (1/2 tbsp; Carlson) DIM (200 mg; Nature's Way) Magnesium (500mg; Life Extension) Chromium Picolinate (500mcg; Solgar) Vitamin D-3 (5000 IU; NOW) Calcium D-Glucarate (2000 mg; Source Naturals) Sunflower Lecithin (400mg; NOW) Vitamin C (2 g; Nature's Way) Probiotics (Align and Pearls) Vitamin A (10,000 IU; Source Naturals) Melatonin (2 mg; Source Naturals) Grape Seed Extract (200mg; Solgar) I'll post back here with my NutrEval results when they come in. I just wanted to introduce myself and see if anyone had any special insights for me. Thanks!