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Need some advice for methylation protocol.

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Bdeep86, Sep 19, 2013.

  1. Bdeep86

    Bdeep86 Senior Member

    Here is my situation. I have a good B-complex in place (thorne basic b's), I am building hydroxyb12 and dibencozide. I got up to 1000mcg of hydroxy and an 1/8th of diben (source naturals not sure of amount). I started feeling really wiped out, hair falling out, spaced out, fatigue all the time. I figured this is from a possibly folate deficiency issue. I have tried to introduce some methylfolate 400mcg plus whats in complex and I get irritable i'm guessing this is from my COMT status. Could these symptoms be anything other than the B12's possibly causing a folate deficiency? Has this happened to anyone and what was your strategy to get around it? Lower b12's until the folate can catch up?
  2. Those sound very similar to hypothyroid symptoms. How quickly (over what time span), did this happen?
  3. Bdeep86

    Bdeep86 Senior Member

    Yeah it is similar. I'm actually on thyroid medication and ive been good with it for quite some time now. This set in over about 3-5 weeks of building the B12's. This actually happened to me before when building B12's back in june and I just discontinued them because I didn't know what was happening. Then I read about Freddd's folate deficiency theory and it seemed to ring some bells. I also suppose less folate=less bh4 which equals less tyrosine and less T4?
  4. Crux

    Crux Senior Member

    My hair loss was from B12 deficiency. Looks like there are multiple causes.
    It may be a good idea to test RBC folate levels. Not everyone will need supplementation.
    With the dibencozide, I had side effects, although many people have great results, especially against fatigue.
  5. Have you had SNP testing, and if so, can you post them? Any other functional testing for B12, folate, methylation status such as the HDRI methylation panel or the Nutreval test?

    In general, it sounds like a more balanced approach might be better - starting off low with both B12 and folate and gradually increasing those together as tolerated.
  6. Bdeep86

    Bdeep86 Senior Member

    ACE Del16 rs4343 G AG +/-
    ADD1 G460W rs4961 T GG -/-
    ACAT1-02 rs3741049 A GG -/-
    AGT M235T/C4072T rs699 G AG +/-
    AHCY-01 rs819147 C TT -/-
    AHCY-02 rs819134 G AA -/-
    AHCY-19 rs819171 C TT -/-
    BHMT rs16876512 T CC -/-
    BHMT rs6875201 G AA -/-
    BHMT-02 rs567754 T CC -/-
    BHMT-04 rs617219 C AA -/-
    BHMT-08 rs651852 T CT +/-
    BHMT R239Q rs3733890 A AA +/+
    CBS A13637G rs2851391 T CT +/-
    CBS A360A rs1801181 A NO CALL
    CBS C19150T rs4920037 A GG -/-
    CBS C699T rs234706 A GG -/-
    CBS N212N rs2298758 A GG -/-
    COMT rs6269 G GG +/+
    COMT -61 P199P rs769224 A GG -/-
    COMT H62H rs4633 T CC -/-
    COMT V158M rs4680 A GG -/-
    DAO rs2070586 A GG -/-
    DAO rs2111902 G TT -/-
    DAO rs3741775 C AC +/-
    DHFR rs1643649 C TT -/-
    FOLR1 rs2071010 A GG -/-
    FOLR2 rs651933 A AA +/+
    FOLR3 rs7925545 G AA -/-
    FOLR3 rs7926875 A CC -/-
    FUT2 rs492602 G AA -/-
    FUT2 rs601338 A GG -/-
    FUT2 rs602662 A GG -/-
    G6PD rs1050828 T C -
    G6PD rs1050829 C T -
    GAD1 rs3749034 A GG -/-
    GAD1 rs2241165 C TT -/-
    GAD1 rs769407 C CG +/-
    GAD1 rs2058725 C TT -/-
    GAD1 rs3791851 C CT +/-
    GAD1 rs3791850 A GG -/-
    GAD1 rs12185692 A AC +/-
    GAD1 rs3791878 T GT +/-
    GAD1 rs10432420 A GG -/-
    GAD1 rs3828275 T CT +/-
    GAD1 rs701492 T CT +/-
    GAD1 rs769395 G AG +/-
    GAD2 rs1805398 T GG -/-
    GAMT rs17851582 A GG -/-
    GAMT rs55776826 T CC -/-
    GIF (TCN3) rs558660 A GG -/-
    MAO A R297R rs6323 T T +
    MAT1A rs72558181 T CC -/-
    MTHFD1 C105T rs1076991 C CC +/+
    MTHFD1 G1958A rs2236225 A AA +/+
    MTHFD1L rs11754661 A NO CALL
    MTHFD1L rs17349743 C CT +/-
    MTHFD1L rs6922269 A GG -/-
    MTHFD1L rs803422 A GG -/-
    MTHFR 03 P39P rs2066470 A GG -/-
    MTHFR A1298C rs1801131 G TT -/-
    MTHFR A1572G rs17367504 G AA -/-
    MTHFR C677T rs1801133 A GG -/-
    MTHFR G1793A (R594Q) rs2274976 T CC -/-
    MTHFR rs12121543 A CC -/-
    MTHFR rs13306560 T CC -/-
    MTHFR rs13306561 G AA -/-
    MTHFR rs1476413 T CC -/-
    MTHFR rs17037390 A GG -/-
    MTHFR rs17037396 T CC -/-
    MTHFR rs3737964 T CT +/-
    MTHFR rs4846048 G GG +/+
    MTHFR rs4846049 T GG -/-
    MTHFS rs6495446 C TT -/-
    MTR A2756G rs1805087 G AG +/-
    MTRR A66G rs1801394 G AG +/-
    MTRR H595Y rs10380 T CC -/-
    MTRR K350A rs162036 G AA -/-
    MTRR R415T rs2287780 T CC -/-
    MTRR-11 A664A rs1802059 A GG -/-
    MTRR rs10520873 C CT +/-
    MTRR rs1532268 T CC -/-
    MTRR rs162049 G AG +/-
    MTRR rs3776467 G GG +/+
    MTRR rs9332 A GG -/-
    NOS1 rs3782206 T CT +/-
    NOS2 rs2297518 A AG +/-
    NOS2 rs2274894 T GG -/-
    NOS2 rs2248814 A GG -/-
    NOS3 rs1800783 A AT +/-
    NOS3 rs1800779 G AG +/-
    NOS3 rs3918188 A AC +/-
    NOS3 G10T rs7830 T GT +/-
    NOS3 T786C rs2070744 C CT +/-
    PEMT rs4244593 T TT +/+
    PEMT rs4646406 A TT -/-
    PEMT rs7946 C CT +/-
    SHMT1 C1420T rs1979277 A AG +/-
    SHMT1 rs9909104 C TT -/-
    SHMT2 rs12319666 T GG -/-
    SHMT2 rs34095989 A GG -/-
    SLC19A1 rs1888530 T CC -/-
    SLC19A1 rs3788200 A GG -/-
    TCN1 rs526934 G AA -/-
    TCN2 C766G rs1801198 G CG +/-
    TYMS rs502396 C CC +/+
    VDR Bsm rs1544410 T TT +/+

    I had my serum b12 tested years ago and it was very elevated without supplementing at the time.
  7. Harry35


    Bdeep, where did you get that list of SNPs from?
  8. Freddd

    Freddd Senior Member

    Salt Lake City
    Hi BDEEP86,

    100mcg a day of active b12 is enough to use any amount of folate. You can't control folate by cutting out active b12. Obviously you are not forming cells. You may need MeCbl for successful healing. You may need L-carnitine fumarate for successful cell formation. B12 does not cause folate deficiency. When low b12 causes folate deficiency symptoms it is possibly methyl trap. Fatigue all the time could be low potassium. Irritability could be low potassium and/or too much AdoCbl compared to MeCbl in the brain. Fatigue all the time can be lack of carnitine or MeCbl or lack of an effective AdoCbl.

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