Hi!
My lab tests are showing that, due to detoxification issues (leaky gut for sure, probably heavy metals?) all the stuff from the methionine cycle is shunted away to pruduce glutathione. So there's not enough methionine/sam-e for all the other stuff which is in need for methyl groups (like coenzyme q10, carnitine, phospholipds, amico acids with methyl groups, creatine and so on which have all testet low).
My doctor told me to try choline as it's stimulating the parasympathicus. Unfortunately I am prone to asthma and a hyperreactive bronchial system and choline which is metobilized into acetylcholine can lead to bronchial constriction (which it did in my case).
Unfortunately I am very sympathetic-dominant whith lots of catecholimanines in my system (dopamine, norepinephrine), I guess that's due to low COMT activity. I also guess (but still waiting for the results) that I have a slow MAO-A, because I am high in serotonine and 5htp gives me bad side effects as do all the antidepressants. I already have enough of this stuff. I am only lacking epinephrine as sam-e is needed to put a methyl group on it and I am also lacking cortisol. But trying to boost cortisol made me very hyper and I am already dealing with the more severe kind of chronic insomnia.
Methyl-B12 always rose my body temperture and made be lying awake several nights (tried 1mg shots).
So I ordered liquid sam-e from cellfood. It's only 72 mg in it but I was told it's the equivalent dose of 400 mg of normal sam-e in capsule form. So I started very low with 20 mg and was ok. When I took 50 mg several days in a row I noticed an increase in insomnia/anxiety, similar to what I experienced when I took activated B6 (p5p).
I am also working on fixing my gut and liver problems and hope that over time the methionine will not completely used up for glutathione (which is sky high what is not a bad thing, so I am not depleted). But fixing gut/liver-problems won't be a quick fix and I am looking for ways to improve methylation so that I won't be so much depleted in other stuff which is in need of methyl groups.
So are there any possibilities to counteract the effects of sam-e / methyl-b12? I really can't stand more insomnia.
I know there are other methyl donors like TMG, but aren't they also very stimulating? Am I missing something?
Since I got sick I am not able to tolerate normal doses of supplements or medication any more. Even the third of the lowest available dose can give me serious side effects. Really don't know why, but I also can't tolerate other things like noise, heat and stress.
I am able to tolerate carnitine but it does not help as much as I hoped as I am also defient in creatine, Co10 (very stimulating for me) and testosterone which is all need for muscle strength. My muscles are very very weak and going into spasm easily. Magnesium did nothing for me, maybe I have to increase the dose.
Any appreciations are welcome about how to support methylation!
And sorry for mistakes, I am not a native speaker as you may have noticed ;-)
My lab tests are showing that, due to detoxification issues (leaky gut for sure, probably heavy metals?) all the stuff from the methionine cycle is shunted away to pruduce glutathione. So there's not enough methionine/sam-e for all the other stuff which is in need for methyl groups (like coenzyme q10, carnitine, phospholipds, amico acids with methyl groups, creatine and so on which have all testet low).
My doctor told me to try choline as it's stimulating the parasympathicus. Unfortunately I am prone to asthma and a hyperreactive bronchial system and choline which is metobilized into acetylcholine can lead to bronchial constriction (which it did in my case).
Unfortunately I am very sympathetic-dominant whith lots of catecholimanines in my system (dopamine, norepinephrine), I guess that's due to low COMT activity. I also guess (but still waiting for the results) that I have a slow MAO-A, because I am high in serotonine and 5htp gives me bad side effects as do all the antidepressants. I already have enough of this stuff. I am only lacking epinephrine as sam-e is needed to put a methyl group on it and I am also lacking cortisol. But trying to boost cortisol made me very hyper and I am already dealing with the more severe kind of chronic insomnia.
Methyl-B12 always rose my body temperture and made be lying awake several nights (tried 1mg shots).
So I ordered liquid sam-e from cellfood. It's only 72 mg in it but I was told it's the equivalent dose of 400 mg of normal sam-e in capsule form. So I started very low with 20 mg and was ok. When I took 50 mg several days in a row I noticed an increase in insomnia/anxiety, similar to what I experienced when I took activated B6 (p5p).
I am also working on fixing my gut and liver problems and hope that over time the methionine will not completely used up for glutathione (which is sky high what is not a bad thing, so I am not depleted). But fixing gut/liver-problems won't be a quick fix and I am looking for ways to improve methylation so that I won't be so much depleted in other stuff which is in need of methyl groups.
So are there any possibilities to counteract the effects of sam-e / methyl-b12? I really can't stand more insomnia.
I know there are other methyl donors like TMG, but aren't they also very stimulating? Am I missing something?
Since I got sick I am not able to tolerate normal doses of supplements or medication any more. Even the third of the lowest available dose can give me serious side effects. Really don't know why, but I also can't tolerate other things like noise, heat and stress.
I am able to tolerate carnitine but it does not help as much as I hoped as I am also defient in creatine, Co10 (very stimulating for me) and testosterone which is all need for muscle strength. My muscles are very very weak and going into spasm easily. Magnesium did nothing for me, maybe I have to increase the dose.
Any appreciations are welcome about how to support methylation!
And sorry for mistakes, I am not a native speaker as you may have noticed ;-)
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