I am a little more tired than usual on the rapamycin protocol. Although I have seem glimmers of improvement: for example, there is small church opposite my house, attended by Asian Christians, and after each service, the young children of the families play in the church front garden, shouting and laughing, and generally being noisy, as excited kids are. Normally this sound drives me crazy, due to my ME/CFS sound sensitivity (hyperacusis). But the other day, these kids were playing as usual, but instead of the sound irritating and grating on me as it normally does, I perceived the sound of playing children as joyful and life-affirming, which is unheard of for me. That's probably the way most healthy people will perceive the sound children playing, and it made me realize how terrible a disease ME/CFS is, that turns joyful sounds into a grating cacophony. But this was just a one-off, and so far I have not seen much in the way of symptomatic improvement. Currently I am taking 0.25 mg of rapamycin daily (but with my CYP3A4 inhibitors, this should be equivalent of around 1.25 mg daily).