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Mood swings

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by boo85, Feb 16, 2015.

  1. boo85

    boo85 Senior Member

    Are mood swings usual on supplementation therapy?

    I'm supplementing with little amounts of B12 and MF (125mcg and 50mcg per day respectively.)

    It's really strange because one minute I will feel so sad or anxious then the next minute feel fine, happy even.

    Is this a normal part of healing? Why does it happen?
  2. taniaaust1

    taniaaust1 Senior Member

    Sth Australia
    Maybe your body is having an issue with the form of B12 you are taking? Some mutations dont do well with methyl B12 if you are taking that (I cant think now which common one).
    Mogwai likes this.
  3. TheChosenOne

    TheChosenOne Senior Member

    COMT V158M +/+ in combination with MTHFR C677T +/+ can lead to mood swings.
    I have COMT V158M +/+ with MTHFR C677T +/- and I can relate to this. Some days I feel high energetic on methyl B12 and some days I have to lay down when I take it. shows what kind of B12 you need to take. You should take hydroxy or adenosyl B12.
  4. Hip

    Hip Senior Member

    What you are describing is actually a known symptom of ME/CFS, called emotional lability.

    To have labile emotions means that the emotion you are experiencing can change spontaneously from one minute to the next, without any real cause. Emotional lability may also involve emotions that are strongly exaggerated for no reason, like for example suddenly feeling very incredibly tearful with no apparent cause.

    I am not sure why vitamin B12 and methylfolate should bring this on though.

    TCA antidepressants have some efficacy in treating emotional lability, if you feel that it needs treating.
  5. Gondwanaland

    Gondwanaland Senior Member

    Because they are involved in neurotransmitter regulation?
    PeterPositive likes this.
  6. PeterPositive

    PeterPositive Senior Member

    Personally I've found Adeno-B12 a mood "stabilizer", probably it's an indirect effect. It helps with energy production and when our batteries are better charged the nervous system is probably less prone to highs and lows... at least, it's my (unscientific) speculation :)

    Methyl-B12 is active in the brain and it can work as a stimulant, so it's more of a difficult beast. I have the MTHR double mutation (see signature) but only one COMT snp and have found difficult to integrate it, but in the long run it has helped and now it works well for me. It just took me a heck of a lot of time to adjust to it and increase the dosage.

    Similarly methyl-folate which can trigger anxiety even more easily than Methyl-B12, at least for me.

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