Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Discussion in 'Other Health News and Research' started by Murph, Dec 5, 2018.

  1. Murph

    Murph :)

    Messages:
    1,091
    Likes:
    5,159
    https://www.cell.com/neuron/fulltext/S0896-6273(18)31009-2

    Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

    Published: December 3, 2018DOI:https://doi.org/10.1016/j.neuron.2018.11.018
    Highlights

    • Treatment with L. reuteri rescues social deficits in several ASD mouse models

    • L. reuteri reverses social deficits via the vagus nerve

    • L. reuteri reverses social deficits even in germ-free mice

    • OXTR inhibition prevents L. reuteri’s effects on social behavior and VTA plasticity
    https://www.cell.com/neuron/fulltext/S0896-6273(18)31009-2
     
  2. Murph

    Murph :)

    Messages:
    1,091
    Likes:
    5,159
    It's only in mice but it's a cool study because the intervention is so simple - add one single strain of bacteria. I believe microbiologists were beginning to think everything was ecosystems and no single strain could really help so this is pretty amazing.
     
    ScottTriGuy likes this.
  3. lafarfelue

    lafarfelue Senior Member

    Messages:
    352
    Likes:
    974
    Australia
    Microbes are just fascinating. I love all this research and the evidence it's building.

    L. reuteri is the strain that is being tested/used in probiotic allergy therapy, isn't it? I wonder if there are some 'super strains', so to speak, that play a keystone role in broader ecosystems or functions.
     
    ScottTriGuy likes this.
  4. Murph

    Murph :)

    Messages:
    1,091
    Likes:
    5,159
    Reuteri is one, B.Longum is one, and L.Rhamnosus is another:
    https://www.mcri.edu.au/news/research-trial-shows-evidence-cure-may-be-possible-peanut-allergy
     
    ScottTriGuy and lafarfelue like this.
  5. Jackb23

    Jackb23

    Messages:
    92
    Likes:
    201
    Does anyone know when the me/cfs fecal transplant studies will conclude or if they have started yet? Seems like an approach that if on the right track, could really bring some relief.
     
    ljimbo423 likes this.

See more popular forum discussions.

Share This Page