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Methylation report - feel a bit lost

Discussion in 'Genetic Testing and SNPs' started by TakeMeHomeTonight, Oct 31, 2016.

  1. TakeMeHomeTonight



    I am very new to this. The reason I got my DNA checked is because I've been dealing with some serious fatigue for couple of years now and I am still in graduate school where being fatigued is strongly affecting my performance.

    I run my DNA though Genetic Genie and NutraHacker. Since then, I was trying to make some sense out of it. Overall I thought that I would benefit from Methyl B12 but NutraHacker is telling me to avoid it; it's also telling me to avoid curcumin which I've been taking daily for couple months now. I hear curcumin helps get rid of ammonia and whenever I do prolonged cardio, my sweat smells strongly like ammonia.

    I would appreciate any help deciphering my methylation report and whether I should take methyl B12 and curcumin, or any other supplement I should look into.

    Here's link to my report:

    homozygous mutations:

    VDR Taq AA
    MAO A R297R T
    MTRR A66G
    CBS C699T AA

    heterozygous mutations:

    COMT V158M AG
    COMT H62H CT
    MTHFR A1298C GT
    MTR A2756G

  2. Cheesus

    Cheesus Senior Member

    If methyl b12 doesn't make you feel jittery, which I think is the risk with taking methylated supplements when you have COMT and maybe MTRR (?) mutations, then it should be fine.

    On paper I would theoretically feel very jittery with methyl b12 because I have two homozygous COMT mutations, but the reality is I do fine on it.

    If you can't handle methyl b12 you could always try adb12 (adenosylcobalamin).

    Let your body be your guide. If a supplement is helping then don't stop just because a few of your genes suggest they shouldn't.
    TakeMeHomeTonight likes this.
  3. alicec

    alicec Senior Member

    Genetic Genie is very limited, basically looking at SNPs that Yasko is interested in. Most of these do nothing and are no cause for concern. A few do have some effect but they are common variants - millions of people have them. At best some combinations may make a contribution to health issues, they certainly don't cause them.

    Nutrahacker is not a reliable source of information.

    The claim that people with COMT variants don't tolerate methyl donors is simply Yasko's theory. There is no evidence for it and many people who are COMT +/+ (including myself) have no trouble with them. If you do well on methylB12 and curcumin, keep taking them.

    Here is a post which lists some useful resources for analysing SNPs.

    Of the SNPs you mention, the ones that have some small slowing effect are the MTRR/MTR, the first COMT and the MTHFR. Supplementation with, respectively, methylB12, magnesium and methyl folate may be helpful.
  4. TakeMeHomeTonight


    Thank you for your input.

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