I'm on Fredd's protocol and just added SAM-e (200mg) and TMG three days ago. Since then I've been having increased irritability, anxiety and, well, I guess general bleakness. I'm thinking it's one of these supplements since it coincided with their addition and these negative effects seem to be worse in the evening (I take them in the late afternoon). So I'm wondering if anyone else has had negative effects from SAM-e or TMG? Thanks!