HydroxyB12 vs MethylB12, mechanism question...

[PeterPositive]

Hi,
it seems people who can't process Methyl-B12 can use Hydroxy-B12 with less issues and push it to a higher dosage.

What is not entirely clear to me is what is really the difference...

Let's say I can't tolerate 1mg Methyl-B12 but I can tolerate 4mg OH-B12... In theory a good part of the latter should be turned into Methyl-B12 anyways and I thought I should get the same side effects.

What I understand from Dr.Lynch is that some people cannot tolerate extra Methyl groups, therefore the difference would be that OH-B12 gets methylated by already existing methyl groups instead of adding more by taking the Methyl-B12 directly.

Is this correct, or am I making it too simple?

It also seems that OH-B12 helps people with high oxidative stress, whereas too many methyl groups can raise nitric oxide.

It's quite complicated subject... if you have any clue, please let me know.

 

[Valentijn]

Some supplemented methylB12 will get used immediately, and some will be converted to hydroxoB12 and stored in the liver. The rest will get removed in the urine. So unless there's an issue with converting HydroxoB12 into methylB12, supplementing methylB12 isn't really advantageous compared to supplementing with HydroxoB12.

But methylB12 is much easier to find in shops and online, especially in the US.

 

[PeterPositive]

I see, thanks.
So the idea that extra methyl groups (from Methyl-B12) cause "overdrive" in some people makes sense?
My understanding is that there's a difference between adding more methyl groups vs. using those we already have at our disposal (from folate and other donors)