International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
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Dysmenorrhea (uterus cramp), PG, crashing

Discussion in 'Pain and Inflammation' started by pattismith, Nov 1, 2018.

  1. pattismith

    pattismith Senior Member

    The fact that symptoms cortege from dysmenorrhea is often similar to those of CFS/ME/Fibro questioned me.

    Menses are linked to increased production of prostaglandins PGE2 and PGF2 alpha

    PGE is known to increase sentivity to pain in Dorsal root ganglia, favoring transition from acute pain to chronic pain.

    And Prostaglandins (PGs), which are critical mediators of physiologic processes and inflammation, are largely produced by activated microglia and reactive astrocytes during brain inflammation.

    PGE produce its effects by intracellular calcium signaling.

    I noticed that two treatments relating to PG and calcium signaling are eventually used for Dysmenorrhea,

    Calcium channel blockers (blocking PG action)

    COX inhibitors (blocking production of PG)

    Interestingly Celecoxib (COX2 inhibitor) may be interesting to reduce PG production and neuroinflammation
    WinterWren, Moof and Iritu1021 like this.

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