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Double homozygous MTHRF, MTRR & CBS... Where to start?

Discussion in 'Genetic Testing and SNPs' started by mamabear72, Sep 2, 2016.

  1. mamabear72


    I just received my 23andme results and really don't know where to start. If anyone could interpret my results I would be forever grateful. Thank you!

    Thank you! Screen Shot 2016-09-02 at 11.14.27 AM.png
  2. alicec

    alicec Senior Member

    The MTHFR C677T and MTRRK350A +/+ would both slow the respective enzymes, especially the former.

    Both these enzymatic reactions are required to be functional for methionine synthase (MTR) to work well, so it is a bit of a double whammy.

    Having said that, these variants a fairly common, so they are not going to be the cause of your health problems, though could certainly be making a contribution.

    For MTHFR, supplementation with its cofactor B2 may help stimulate a sluggish enzyme, and supplementation with the end product of the reaction, methylfolate, may also be helpful.

    A slow MTRR may mean the B12 is not recycled well, ie it is in a sense wasted. Supplementation with methylB12 may be helpful.

    Here is a post I wrote recently about more general issues involved with active B12 supplementation.

    The only other SNP which has any consequence is the first COMT. +/- would have a slight slowing of the enzyme. Supplementation with the cofactor magnesium might be helpful.

    It is claimed the COMT SNPs mean intolerance of methyl groups. This is a theory with no evidence, and plenty of people who are COMT +/+ have no trouble with methyl groups.

    Some are very sensitive to supplements like methylfolate and methylB12, so proceed cautiously, but it has nothing to do with COMT.
    Valentijn likes this.

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