Mary
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Are there any negative side effects from "too much methylb12" if the other cofactors are not present in sufficient quantity? Is there any toxicity associated with large amounts?
I don't know. All I know is that I don't have any negative symptoms from large doses of methyl B12. However, I did react quite strongly to large doses of methylfolate - it caused a strong detox reaction for me. I can tolerate, and do well with, 1600 mcg. of methylfolate, but when I bumped it up to 3200 mcg., I was in la la land - most likely mercury detoxing. The symptoms abated when I backed down to my 1600 mcg. a day dose of methylfolate. Meanwhile, I'm taking 10,000 mcg. methyl B12 (sublingual) with no problem.