August 8th, 2018: Understanding and Remembrance Day for Severe ME
Have you heard of our Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance? Please join Jody Smith in observing this day and honoring the 25% of those with ME/CFS who are most severely ill.
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Cortico

Discussion in 'General ME/CFS Discussion' started by lansbergen, Oct 25, 2013.

  1. lansbergen

    lansbergen Senior Member

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    I think I found why dexamethasone worsened the problem

    http://www.fasebj.org/content/16/1/61.full#sec-1

    Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

    First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12). They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.
     
    Valentijn likes this.

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