Hi All,
I’m hoping for some insight from the folks here. I also know Rich has some interest in cases where the protocol didn’t work, and I wanted to provide that feedback.
I've been gearing up to try the simplified methylation protocol. But after going through my notes, I realized I actually did something similar in 2010 (Jan-June), and then after five months of that, did testing. The testing showed low pyroglutamate (29 ug/mg). Rich has said this is a fairly reliable indicator for glutathione depletion.
So it would appear that the treatment didn’t accomplish its primarily goal – raising glutathione? (Even though I don’t have a baseline measurement, I’m presuming it wasn’t much below 29 in January because, compared to a lot of PWC’s, my symptoms aren’t that bad. To be <<29 seems pretty severe.)
This deviates quite a bit from the protocol, but Rich says the essence of the protocol is taking healthy doses of folate (5-MTHF) and B12:
* 1mg 5-MTHF
* 1mg sublingual methylcobalamin
* 50-100mg B6 (P5P). (Bear in mind that I think I may have the CBS upregulation, based on my urine amino acid results and Dr. Yasko's comments on this. B6 may not have been a good idea.)
* 30mg B3 (it looks like these are the only B’s I took – no B1/B2)
* Mg, Zn, Mo, Mn, and Li
* Betaine HCl
* Herbals for dysbiosis (garlic, uva ursi, grapeseed extract)
* And some other things that are doubtful to be related
My test results are attached. The urine/plasma amino acids were taken on the same day; organic acids three weeks later.
Symptom-wise, during that time, my notes show a variety of uncomfortable symptoms, but allergy season messes me up anyway. Mostly I think I was OK.
My question is, why did my glutathione seem to not rise?
* Deviations from the protocol (too much / too little / different types)
* Insufficient B1/B2? (I’m sure my food was providing some, but not enough?)
* Can overmethylation cause glutathione to stay low?
* Can aggravation of a CBS upregulation (via B6) cause glutathione to stay low?
* Are metals interfering?
* Dysbiosis? (But I think I have too many plasma amino acids showing good absorption, for this to be the case)
Or even with my low pyroglutamate, maybe glutathione really did come up a little?
A month ago, my serum B12, B6, and “folic acid” were tested. The B12/B6 were low but in the lab's range -- I hadn’t been supplementing at all since 2010. My “folic acid” was fairly normal.
I’m planning to do these tests in the next couple weeks:
* organic acids
* plasma amino acids
* methylation panel
* 23andme
But I’m debating whether I should try the methylation protocol (exactly, this time), or first work on metals via Cutler. (I was hoping to let glutathione do that work naturally instead...)
Anyone have thoughts?
Thank you -
Vance
I’m hoping for some insight from the folks here. I also know Rich has some interest in cases where the protocol didn’t work, and I wanted to provide that feedback.
I've been gearing up to try the simplified methylation protocol. But after going through my notes, I realized I actually did something similar in 2010 (Jan-June), and then after five months of that, did testing. The testing showed low pyroglutamate (29 ug/mg). Rich has said this is a fairly reliable indicator for glutathione depletion.
So it would appear that the treatment didn’t accomplish its primarily goal – raising glutathione? (Even though I don’t have a baseline measurement, I’m presuming it wasn’t much below 29 in January because, compared to a lot of PWC’s, my symptoms aren’t that bad. To be <<29 seems pretty severe.)
This deviates quite a bit from the protocol, but Rich says the essence of the protocol is taking healthy doses of folate (5-MTHF) and B12:
* 1mg 5-MTHF
* 1mg sublingual methylcobalamin
* 50-100mg B6 (P5P). (Bear in mind that I think I may have the CBS upregulation, based on my urine amino acid results and Dr. Yasko's comments on this. B6 may not have been a good idea.)
* 30mg B3 (it looks like these are the only B’s I took – no B1/B2)
* Mg, Zn, Mo, Mn, and Li
* Betaine HCl
* Herbals for dysbiosis (garlic, uva ursi, grapeseed extract)
* And some other things that are doubtful to be related
My test results are attached. The urine/plasma amino acids were taken on the same day; organic acids three weeks later.
Symptom-wise, during that time, my notes show a variety of uncomfortable symptoms, but allergy season messes me up anyway. Mostly I think I was OK.
My question is, why did my glutathione seem to not rise?
* Deviations from the protocol (too much / too little / different types)
* Insufficient B1/B2? (I’m sure my food was providing some, but not enough?)
* Can overmethylation cause glutathione to stay low?
* Can aggravation of a CBS upregulation (via B6) cause glutathione to stay low?
* Are metals interfering?
* Dysbiosis? (But I think I have too many plasma amino acids showing good absorption, for this to be the case)
Or even with my low pyroglutamate, maybe glutathione really did come up a little?
A month ago, my serum B12, B6, and “folic acid” were tested. The B12/B6 were low but in the lab's range -- I hadn’t been supplementing at all since 2010. My “folic acid” was fairly normal.
I’m planning to do these tests in the next couple weeks:
* organic acids
* plasma amino acids
* methylation panel
* 23andme
But I’m debating whether I should try the methylation protocol (exactly, this time), or first work on metals via Cutler. (I was hoping to let glutathione do that work naturally instead...)
Anyone have thoughts?
Thank you -
Vance