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Can magnesium improve the symptoms of POTS?

Discussion in 'Problems Standing: Orthostatic Intolerance; POTS' started by men100, Sep 1, 2018.

  1. men100


    A week ago I started taking a medicine that is in Spain called CN Base and has many components of vitamins and minerals. A few days later I noticed an improvement in the post-exertion fatigue (it was more tolerable) and I notice that the pulsations go up less than before. I have not tried to walk more than I can usually do, because I do not want to force my body either. But of course, the fatigue has been less. After waiting a few days to confirm it, I think it is some component of the medicine and I deduce that it is magnesium. I do not know if I have a deficit or not, in the test of metals and minerals in the hair follicle of the hair it came out in addition to high several metals, low in magnesium and potassium. Potassium in blood is always in range, but magnesium has never looked at it in blood.

    I have read in some places that magnesium can relieve the symptoms of POTS in some people, I imagine that because they have a deficit (the deficit gives dysautonomic symptoms apparently). What worries me, to put it somehow, is that the CN Base drug only brings 40mg. per capsule and sometimes at rest with the heart rate monitor of 60 beats per minute and occasionally I have reached 47. I had thought about taking more magnesium separately but it seems that if there is excess it can cause serious symptoms such as sudden hypotension that can leave you unconscious.

    One capsule CN Base contains:

    Retinol acetate (vit A) 340 μg retinol
    Colecalciferol (vit D3) 7.5 μg
    Succinate of D-alpha-tocopheryl (vit E) 10 mg of alpha-tocopherol
    Calcium ascorbate (vit C) 150 mg of vitamin C
    Thiamine hydrochloride (vit B1) 4.2 mg.
    Riboflavin-5-phosphate (vit B2) 4.8 mg.
    Niacinamide or Nicotinamide (vit B3) 7 mg.
    Calcium D-pantothenate (Vit B5) 4 mg
    Pyridoxal 5-phosphate (vit B6) 6 mg
    Biotin (vit B7) 75 μg
    Calcium L-Methylfolate (vit B9) 150 μg of folate
    Methylcobalamin (vit B12) 3 μg
    Calcium citrate 25 mg calcium
    Total calcium 37 mg
    Magnesium citrate 37.5 mg of magnesium
    Zinc citrate 5 mg zinc
    Copper citrate 0.50 mg copper
    Manganese Citrate 0.80 mg manganese
    Sodium molybdate 15 μg molybdenum
    Sodium selenite 50 μg selenium
    Chromium picolinate 65 μg chrome
    R-lipoic acid 50 mg
    Coenzyme Q10 fermented 50 mg
    Natural additives: silicon dioxide and microcrystalline cellulose.
  2. LINE

    LINE Senior Member

    RDA for magnesium is 300-350mg per day. Magnesium is probably one of the most important minerals since it controls so many enzymatic functions. Magnesium is quite sensitive to stress, meaning when the system is stressed (not just emotional but biological stress which includes infections, trauma etc) then magnesium is lost. Cardiovascular and muscles are quite dependent on magnesium as are the stress/adrenal components.

    Magnesium is also dependent on other nutrients much like everything else in the body. Magnesium comes in many forms, so you have to find the one that works, it sounds like this form is working. I found that mag lysinate mixed with mag glycinate are particular effective for me. I stay away from oxide, citrate, orotate forms.

    Dr. Mildred Seelig, M.D. was perhaps the best mag researcher and wrote many pivotal articles which can be found here:

    This article deals specifically with CFS/ME and magnesium
  3. LINE

    LINE Senior Member

    Some statements that came from the last link (

    The evidence that Mg deficiency causes a variety of both humoral and cellular defense disturbances, among which are several that have been identified in CFS and FM, is a reason to suspect that either Mg deficiency or its abnormal utilization might be a pathogenic factor in CFS. It has been suggested that the immunologic response to infection that often precedes CFS may be linked to the nervous system and to catecholamine release and to that of pituitary hormones (235). An intriguing hypothesis: "neurogenic switching" ties together allergies (e.g., of "sick building syndrome" or multiple chemical sensitivity syndrome) with immunogenic inflammation and neurogenic inflammation, mediated by substance P or other neuropeptides (236).

    The use of Mg, as one of the down-regulators of NMDA firing, has been suggested to control the immune disease manifestations of CFS, and the evidence of free radical injury to the brain in CFS (239) supports the rationale for combined Mg and antioxidant therapy in CFS. The finding that Mg deficiency is associated with free radical production, (as well as having direct effects on immunologic mechanisms) suggests that the Mg effect might be enhanced by adding antioxidants to Mg treatment also of LTS. It is provocative that magnesium and taurine (an antioxidant amino acid) has been proposed as therapy for migraine (132) and for the complex of complaints termed electromagnetic dysthymia, which includes CFS as an extreme case (233).
  4. Thinktank

    Thinktank Senior Member

    Magnesium worsens my orthostatic intolerance because it's a vasoDILATOR. Anything with vasodilating effects worsens it for me. Anything that stimuates adrenaline/NMDA improves my orthostatic intolerance / POTS / dysautonomia whatever it is.
  5. men100


    @Thinktank , but in case of deficit it seems to cause symptoms like those of the POTS. I do not know if it was magnesium or another component of CN Base, but if I read that there are people who have improved POTS with magnesium, I imagine they would have a deficit. My dilemma is now whether to increase magnesium dose or can be dangerous precisely because, being vasodilator ...

    Also I will start the ketogenic diet and it is assumed that you have to take more magnesium, sodium and potassium because many mineral salts are lost.
  6. Peyt

    Peyt Senior Member

    Magnesium makes POTS worst!(so does Niacinamide ) Anything the dilates blood vessels makes POTS worst..
    What I see in that formula that is helpful is Thiamine.
    Many people who are supposedly diagnosed for POTS really have another condition called BeriBeri. The symptoms are very similar. The cure for BeriBeri is Thiamine.

    Also, Riboflaven in the formula could be helpful as well but Thiamine deficiency should be addressed first.

    Also, I have learned the hard way never to take any supplements that have so many things in them. Chances are some of the vitamins or minerals in the formula are no good for POTS people. IMHO
    Last edited: Jan 13, 2019 at 12:42 PM

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