Hi All,
Apologies in advance for the lengthy post. I’m new to this forum and I’d love input on the following if you have the time.
I'm a 34-year-old female. I started a methylation protocol about 6-7 weeks ago, and as many of you have noted in your experience, my main symptom (intense leg muscle weakness) has worsened. I can’t tell if this is detox, or just an exacerbation of symptoms that has nothing to do with detox, or what.
For the past year and half, when my mitochondrial dysfunction/muscle weakness started, I’ve had difficulty walking up stairs, exerting myself, etc. I had and still have a profound muscle weakness in my legs, and an obvious lack of ATP. While sometimes I can become incredibly tired even after a lot of sleep, the muscle weakness is the one glaring symptom that prevents me from doing so many things.
Since starting the protocol several weeks ago, my symptoms have intensified and I’ve become considerably weaker. My muscles are tighter and insanely stiff. My legs feel even heavier than before. I added potassium into the mix about a month ago, and immediately took 1800mg a day (600mg each meal). That dosage really helped with the stiffness and I noticed a difference immediately, but now as a few more weeks have passed, the stiffness has returned (I’m still taking 1800mg potassium daily). Should I be taking more than that? I had my potassium checked during the midst of all of this (while taking that much) and my levels were 4.3, which is technically mid-range.
I’ve had my homocysteine and MMA tested, and both were within range. I had the Metametrix Organic Acids Urine test done a month or two ago, and learned that I had High B-Hydroxybutyrate, High Malate, High FIGLU, and High Homovanillate. Further to those tests, I had the Amino Acids panel from Vitamin Diagnostics Inc completed, and the following was found:
Glutathione oxidized - .52 (slightly high)
Glutathione Reduced – 3.2 (low)
SAM – 212 (low)
SAH – 49.8 (slightly high)
5-CH3-THF – 8.8
10-Formyl-THF – 3.3
5-Formyl-THF – 3.90
THF - .56 (low)
Folic Acid – 11.6
Folinic Acid – 9.3
Folic Acid, Active (RBC) – 356 (low)
Adenosine – 23.8 (high)
As part of my treatment protocol, I take the following daily per my clinician’s recommendations:
4 pumps of Methylmate B12 nasal spray (said to be absorbed better nasally)
2 capsules Thorne MethylGuard (contains B6, 5-MTFH. Methylcobalamin, and TMG)
200mg SAM-E
150mg CoQ10
100 mg Alpha-Lipoic Acid
400 mcg Chromium
200 mcg Vanadium
800mg magnesium citrate
4000iu vitamin d
10 mg NADH – heard this might help
PQQ – I just started this – heard it could help
D-Ribose – I tried this for two weeks but it didn’t really do anything so I have stopped it. Maybe I will try again
Vitamin C – I can’t take this any longer (even in small doses) because it ruins me digestively
My main question is this: How long does the said “exacerbation of symptoms” supposedly go on? I am trying my best to be optimistic about this, and I know this is going to be a long journey and it’s not a cure-all, but am feeling incredibly frustrated and saddened and I guess I just need some hope. My symptoms, while intense, are technically bearable (I CAN walk up stairs, it’s just really damn difficult and I have trouble breathing while doing so). I just want to make sure I’m not making things worse. Has anyone had similar experiences with this muscle weakness/mitochondrial dysfunction?
If anyone has any thoughts on the above, and feel like sharing, I’d love to hear your opinions.
Many thanks for your help, it means a lot.
Sincerely,
Caitlin
Apologies in advance for the lengthy post. I’m new to this forum and I’d love input on the following if you have the time.
I'm a 34-year-old female. I started a methylation protocol about 6-7 weeks ago, and as many of you have noted in your experience, my main symptom (intense leg muscle weakness) has worsened. I can’t tell if this is detox, or just an exacerbation of symptoms that has nothing to do with detox, or what.
For the past year and half, when my mitochondrial dysfunction/muscle weakness started, I’ve had difficulty walking up stairs, exerting myself, etc. I had and still have a profound muscle weakness in my legs, and an obvious lack of ATP. While sometimes I can become incredibly tired even after a lot of sleep, the muscle weakness is the one glaring symptom that prevents me from doing so many things.
Since starting the protocol several weeks ago, my symptoms have intensified and I’ve become considerably weaker. My muscles are tighter and insanely stiff. My legs feel even heavier than before. I added potassium into the mix about a month ago, and immediately took 1800mg a day (600mg each meal). That dosage really helped with the stiffness and I noticed a difference immediately, but now as a few more weeks have passed, the stiffness has returned (I’m still taking 1800mg potassium daily). Should I be taking more than that? I had my potassium checked during the midst of all of this (while taking that much) and my levels were 4.3, which is technically mid-range.
I’ve had my homocysteine and MMA tested, and both were within range. I had the Metametrix Organic Acids Urine test done a month or two ago, and learned that I had High B-Hydroxybutyrate, High Malate, High FIGLU, and High Homovanillate. Further to those tests, I had the Amino Acids panel from Vitamin Diagnostics Inc completed, and the following was found:
Glutathione oxidized - .52 (slightly high)
Glutathione Reduced – 3.2 (low)
SAM – 212 (low)
SAH – 49.8 (slightly high)
5-CH3-THF – 8.8
10-Formyl-THF – 3.3
5-Formyl-THF – 3.90
THF - .56 (low)
Folic Acid – 11.6
Folinic Acid – 9.3
Folic Acid, Active (RBC) – 356 (low)
Adenosine – 23.8 (high)
As part of my treatment protocol, I take the following daily per my clinician’s recommendations:
4 pumps of Methylmate B12 nasal spray (said to be absorbed better nasally)
2 capsules Thorne MethylGuard (contains B6, 5-MTFH. Methylcobalamin, and TMG)
200mg SAM-E
150mg CoQ10
100 mg Alpha-Lipoic Acid
400 mcg Chromium
200 mcg Vanadium
800mg magnesium citrate
4000iu vitamin d
10 mg NADH – heard this might help
PQQ – I just started this – heard it could help
D-Ribose – I tried this for two weeks but it didn’t really do anything so I have stopped it. Maybe I will try again
Vitamin C – I can’t take this any longer (even in small doses) because it ruins me digestively
My main question is this: How long does the said “exacerbation of symptoms” supposedly go on? I am trying my best to be optimistic about this, and I know this is going to be a long journey and it’s not a cure-all, but am feeling incredibly frustrated and saddened and I guess I just need some hope. My symptoms, while intense, are technically bearable (I CAN walk up stairs, it’s just really damn difficult and I have trouble breathing while doing so). I just want to make sure I’m not making things worse. Has anyone had similar experiences with this muscle weakness/mitochondrial dysfunction?
If anyone has any thoughts on the above, and feel like sharing, I’d love to hear your opinions.
Many thanks for your help, it means a lot.
Sincerely,
Caitlin