Hi, this is my first post, hopefully some of you knowledgeable people out there can help!
I've been suffering from extreme exhaustion for the last 18 months following a nasty virus which hit at a particularly busy/stressful time, and it knocked me out completely. I've had ups and downs since, but never returned to more than 50% energy levels and the medical profession have basically said "it's ME/CFS - go home till it gets better" !
A couple of months ago I started on a version of Rich/Freddd's methylation programme, starting at low doses and gradually working up. I've also got back results from 23andme (see below) and saliva cortisol test (morning cortisol is low, just outside normal range) plus all the usual bloods (all within normal range). The Genetic Genie Methylation Profile shows:
+/+ for:
BHMT-02
BHMT-08
+/- for:
COMT V158M
COMT H62H
VDR Bsm
VDR Taq
MTHFR C677T
MTHFR 03 P39P
MTHFR A1298C
MTRR A66G
AHCY-01
AHCY-19
So I'm wondering if I should be taking anything for the BHMT +/+? I've seen suggestions of TMG but wondered if anyone had any experience of this? Also will TMG create more methyl groups, and is this a good thing given the various +/- above? I did wonder if I should be taking hydroxy-B12 rather than methyl-B12 if I introduce TMG?
I'm currently taking:
Cheers,
Mark
I've been suffering from extreme exhaustion for the last 18 months following a nasty virus which hit at a particularly busy/stressful time, and it knocked me out completely. I've had ups and downs since, but never returned to more than 50% energy levels and the medical profession have basically said "it's ME/CFS - go home till it gets better" !
A couple of months ago I started on a version of Rich/Freddd's methylation programme, starting at low doses and gradually working up. I've also got back results from 23andme (see below) and saliva cortisol test (morning cortisol is low, just outside normal range) plus all the usual bloods (all within normal range). The Genetic Genie Methylation Profile shows:
+/+ for:
BHMT-02
BHMT-08
+/- for:
COMT V158M
COMT H62H
VDR Bsm
VDR Taq
MTHFR C677T
MTHFR 03 P39P
MTHFR A1298C
MTRR A66G
AHCY-01
AHCY-19
So I'm wondering if I should be taking anything for the BHMT +/+? I've seen suggestions of TMG but wondered if anyone had any experience of this? Also will TMG create more methyl groups, and is this a good thing given the various +/- above? I did wonder if I should be taking hydroxy-B12 rather than methyl-B12 if I introduce TMG?
I'm currently taking:
- Methyl-B12 (sublingual 500mg jarrow formulas) - started on 1,000mg but after the first week it was too exhausting so had to drop the dose. This still makes makes me more tired than before I started taking it, but I've read that if my body doesn't need it there will be no reaction, so maybe this is a good sign?
- Methylfolate (400ug solgar metafolin)
- Adenosyl-B12 (1,000mg metabolics capsule)
- Various vitamins including: multivitamin, C, D, zinc, magnesium, potassium, fish oil.
Cheers,
Mark