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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. ppodhajski

    When "Common SNPs" Matter

    @ahmo....THIS is great. SUOX (Sulfite Oxidase) is responsible for turning Sulfite into sulfate. When people have this SNP they will be sulfite sensitive if they are low in the cofactor for the gene, Molybdenum. You are homozygous for this and it definitely will slow down your your conversion...
  2. ppodhajski

    Chronic Brain Fog & Genome Data Help?

    Regarding just the brain fog, would you mind looking up a SNP for me in your 23andme data? SUOX rs10876864
  3. ppodhajski

    Dopamine concern

    Oh my, @ahmo, look at this! I never looked this up before. It suddenly dawned on me this morning that I never looked up the cofactor for FLAD1 which turns FMN into FAD and there iit is, it uses MAGNESIUM as a cofactor! AND it uses an ATP molecule as well. No wonder why magnesium relaxes most...
  4. ppodhajski

    Dopamine concern

    Interesting about you histamine a but it makes sense! The enzyme that breaks down histAMINE is Diamine Oxidase (DAO) and guess what it used as a cofactor.......FAD! So I will guess if we look at you DAO SNPs we would see a lot of lie frequency genes. The next gene in that pathway is HNMT which...
  5. ppodhajski

    Dopamine concern

    Give me a break with this stuff. We all know we all are just putting our own hypothesis out here. No one has scientifically studied my method so there is no evidence. There is plenty of evidence for the subsets of my theory. I did. I cannot find a single hole in my method. Because I started...
  6. ppodhajski

    What are the symptoms of ACAT issues?

    First, I use the term FMN because it fits with the biology. riboflavin-5′-phosphate is the same as flavin mononucleotide. But riboflavin-5′-phosphate Sodium is not that same as flavin mononucliotide. There is only one company I know of that sells flavin mononucliotide (E101) without the sodium...
  7. ppodhajski

    Dopamine concern

    Riboflavin-5′-phosphate and Riboflavin-5′-phosphate Sodium is not the same. No. But someone has to be the first to discover something. I have seen this in action in two people. And look at here on this forum...
  8. ppodhajski

    When "Common SNPs" Matter

    Can you look up a SNP for me? SUOX rs10876864
  9. ppodhajski

    Unfolded Protein Response and A Possible Treatment for CFS

    Simple. It is not a cofactor so I do not supplement with it. SHMT is the enzyme that intraconverts serine and glycine and uses P5P as a cofactor. I think if you have enough B6 your body will make what it needs. http://www.uniprot.org/uniprot/P34896 No SHMT genes in 23andme. :( However...
  10. ppodhajski

    When "Common SNPs" Matter

    Yes, I think there is only one selenium thread but we talked about it in another as well, the one on UPR I think? First for the cholesterol, look up your MYRF gene. rs174537. T is the slow allele which leads to lower cholesterol/ I finally have a good one on this (T,T) but I am afraid it leads...
  11. ppodhajski

    When "Common SNPs" Matter

    So you do not even believe the researchers? http://www.uncnri.org/index.php/steven-h-zeisel/
  12. ppodhajski

    Dopamine concern

    OK
  13. ppodhajski

    What are the symptoms of ACAT issues?

    That form of B2 it is not the same. It is closely related but not the same. https://en.wikipedia.org/wiki/Flavin_mononucleotide#Food_additive Source Naturals makes a pure form of FMN (Sublingual coenzymated B2). Any dose will depend on your own needs, start low and go slowly. And yes, that is...
  14. ppodhajski

    Dopamine concern

    I am not talking about how the SNP causes Autism. Just mood disorders in general. That is the issue you have with trying to understand Nutritional Genomics and Metabolic Pathways. If I did everything you said I would not be better. So there is that as well.
  15. ppodhajski

    Bill Walsh Finally Explains Over-Methylation In A Way I Can Understand

    Sorry, that was supposed to be B6
  16. ppodhajski

    What are the symptoms of ACAT issues?

    And while there is little research that Rs3741049 SNPs chafe the metabolic rate of the SNPs there is no evidence that it does not either. In most cases we can assume that there is a change since that is the reason for most SNPs in the first place.
  17. ppodhajski

    What are the symptoms of ACAT issues?

    When common SNPs matter. http://forums.phoenixrising.me/index.php?threads/when-common-snps-matter.39635/
  18. ppodhajski

    When "Common SNPs" Matter

    I have the same SNPs, Eggs will work fine for most people, no need to buy supplements.
  19. ppodhajski

    Bill Walsh Finally Explains Over-Methylation In A Way I Can Understand

    HCY test would just measure where in the cycle you are stuck. If you are B2, B12, or Zinc deficient this would stop you from recycling methionine. Add a N6 deficiency and your HCY is higher, Eating more methionine would just make HCY higher.
  20. ppodhajski

    Bill Walsh Finally Explains Over-Methylation In A Way I Can Understand

    SAM is used by several methyltransferases, like COMT and HNMT, to degrade catecholamines (serotonin, dopamine, epinphereine). It makes sense that if SAMe si too high or low you can have mood issues. Note the MT on the end of those genes stands for methyltransferase...
  21. ppodhajski

    Dopamine concern

    First, I do not call it R5P, I call it FMN. There is a reason I do so. What is it exactly that you think vitamins do if they do not effect gene expression? You do not understand Nutritional Genomics. Read for a few days, watch some videos. You do not want to learn anything from me so learn it...
  22. ppodhajski

    IBS - I need some advice

    As someone who has cured his IBS-D after 20 years I have some things you might try. I was exactly like you for three months once. The three things that I feel cured it were: 1)Cod Liver Oil, it has -Vitamin A that helps produce bile acids and helps lower serotonin -omega 3's and D which also...
  23. ppodhajski

    Neurogenic Bladder or Overactive Bladder Anyone?

    Do you drink tea?
  24. ppodhajski

    Dopamine concern

    You are talking to one. And I worked with others that do not have ME. (arthritis, anxiety, anger, heart palpitations). @ahmo is another on the board. I called out his need for B2 as well by looking at his genetics. But even if there is no one else there always has to be a first. Maybe if you...
  25. ppodhajski

    What evidence is there that ME/CFS is more autoimmune than chronic infection?

    Since I cured my ME, IBS, IC with Nutritional Genomics I will say it is autoimmune without a doubt.
  26. ppodhajski

    intro and genetic testing 8-2015

    http://forums.phoenixrising.me/index.php?threads/when-common-snps-matter.39635/
  27. ppodhajski

    When "Common SNPs" Matter

    Short video,2 minutes, where Dr. Steven Zeisel explains; "We are reporting how there common SNPs change whether you need choline or not". http://epigenie.com/snps-nutrition-and-dna-methylation-with-dr-steven-zeisel/ So can we end the "it's common so it does not matter" debate and get on with...
  28. ppodhajski

    intro and genetic testing 8-2015

    Let me know what you have questions about and we will go from there!
  29. ppodhajski

    Dopamine concern

    Enzymes work the same no mater what the organism. But if that is too much for you to get right now here is one that shows genes in a human cell line. Common gene expression patterns responsive to mild temperature hyperthermia in normal human fibroblastic cells...
  30. ppodhajski

    Dopamine concern

    Yes, the genes stay the same but the enzyme activity of the gene can change from quite a few factors. Age http://www.genomebiology.com/2013/14/7/R75 Cofactor and Coenzyme availability http://www.ncbi.nlm.nih.gov/pubmed/16214324 http://www.ncbi.nlm.nih.gov/pubmed/10089110 As well as...