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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Search results

  1. uglevod

    I may have Lyme, need advice!

    Lyme is one of those pathogens(other includes EBV CMV) suppressing VDR(vitamin D receptor): https://mpkb.org/home/pathogenesis/vitamind/metabolism Another one is Mycobacteria and 15..30% of the world population is already chronically infected with it (latent intracellular undiagnosed form).
  2. uglevod

    The dark side of Vitamin D supplements and chronically high D25 levels

    Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein: https://pubmed.ncbi.nlm.nih.gov/11728340/ Inhibition of IFN-γ Signaling by Glucocorticoids: https://www.jimmunol.org/content/170/9/4833 https://pubmed.ncbi.nlm.nih.gov/12707366/ Addition of dexamethasone to...
  3. uglevod

    Getting groggy and weak from small amounts of sunshine

    Immune activation effect - check out for the followup weight loss(like during sleep). Especially effective if you have low levels of D25.
  4. uglevod

    The dark side of Vitamin D supplements and chronically high D25 levels

    Enhanced LL-37 expression following vitamin D supplementation in patients with cirrhosis and spontaneous bacterial peritonitis https://pubmed.ncbi.nlm.nih.gov/26058412/ Background & aims: The morbidity and mortality of spontaneous bacterial peritonitis (SBP) are high among patients with...
  5. uglevod

    Fluctuation of serum vitamin E concentrations during exacerbation and remission phases in patients with CFS

    Probably we are all chronically(sublinically) septic: Fluctuation of serum vitamin E (α-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome https://link.springer.com/article/10.1007/s00380-009-1206-6 The etiology of chronic fatigue...
  6. uglevod

    Positive toxoplasmosis igm and igg

    Interesting, thanks for posting this. https://en.toxoplasmachronic.com/2-faelle-mit-positivem-ltt I developed a Revolving Therapy concept, which proofed to be highly effective in these cases - this is one of the possible combinations I prescribe in many cases: - Pyrimethamine 25 mg 2 x 1...
  7. uglevod

    Positive toxoplasmosis igm and igg

    Evaluation of nitazoxanide(alinia) as a novel drug for the treatment of acute and chronic toxoplasmosis https://pubmed.ncbi.nlm.nih.gov/30986380/ Significant Reduction of Brain Cysts Caused by Toxoplasma gondii after Treatment with Spiramycin Coadministered with Metronidazole in a Mouse Model...
  8. uglevod

    Positive toxoplasmosis igm and igg

    like 25% of the world population is chronically infected personally i have high igg titre
  9. uglevod

    Vitamin A, Retinoids and Mitochondrial Dysfunction

    its about withdrawal from vit A metabolites, not supplementation...
  10. uglevod

    Vitamin A, Retinoids and Mitochondrial Dysfunction

    Bump. This stuff is really interesting. https://ggenereux.blog/2020/11/12/2020-community-survey-results/
  11. uglevod

    High-Dose Selenium Significantly Improves My Fatigue and Brain Fog

    Tx @Hip, additionally selenium could restore immunocompetence of macrophages, so no wonder immune system starts to panic in case of its deficiency and as a result overload body with pro infl cytokines like it always prefers to do in many other cases like low levels of vitamins, other minerals...
  12. uglevod

    My New Treatment Strategy (Supplements were too helpful)

    I'am afraid all those keto diets are just playing around cortisol(stress hormone) levels and its influence over the immune system.
  13. uglevod

    Pentoxifylline, dexamethasone and azithromycin demonstrate synergistic inhibition of TLR- and inflammasome

    well, that could be dangerous, since you'd be losing resistance towards many infections including covid https://www.frontiersin.org/articles/10.3389/fphar.2020.601685/full...
  14. uglevod

    Pentoxifylline, dexamethasone and azithromycin demonstrate synergistic inhibition of TLR- and inflammasome

    Yeah, but zith is dose dependent until you overdo, it mainly resides in macrophages without much influence over TLRs. most of the drugs are TLR inhibitors, including vitamins, etc quercetin: https://pubmed.ncbi.nlm.nih.gov/27665434/ vitamin a: https://pubmed.ncbi.nlm.nih.gov/23086657/...
  15. uglevod

    My New Treatment Strategy (Supplements were too helpful)

    All your supplements are TLRs antagonists so no wonder you are getting an inflammation spike upon withdrawal...
  16. uglevod

    Anyone treating oxalates /on a low oxalate diet?

    Yes, I'am doing this stuff (zero2low oxalates diet). Oxalates are immunomodulators and instant withdrawal often leads to system wide inflammation (so called "detox") and an urge to consume other suppressants.
  17. uglevod

    Antidepressants

    Antidepressants are another class of immune suppressing drugs. Forget everything you read on them in plain media/pharma controlled "science" for your own good. Antidepressants normalize elevated Toll-like receptor profile in major depressive disorder...
  18. uglevod

    BBC Horizon says taking antioxidants results in a 12% increase in mortality, and cancels out some of the health benefits of exercise

    Antioxidants just forces your immune system to see less bacteria/viruses than there are really are: https://forums.phoenixrising.me/threads/dark-side-of-antioxidants.81580/ Also they help to spread cancer cells as a bonus(due to increased immune deficiency)...
  19. uglevod

    Fixing Leaky Gut Helps ME/CFS, and Sometimes Achieves Full Remission

    So, anyone recovered via healing gut/suppressing LPS translocation, or its another temporary remission as always?
  20. uglevod

    Anecdotal Experiences with Whey Protein Supplementation?

    Maybe without whey your gut has started to leak more bacteria/toxins: Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro...
  21. uglevod

    Dietary stearic acid induces mitochondrial fusion in humans. Relevance for ME/CFS?

    They are not totally in-cell abxs https://en.wikipedia.org/wiki/Cathelicidin Higher plasma levels of human cathelicidin antimicrobial protein (hCAP18) appear to significantly reduce the risk of death from infection in dialysis patients.
  22. uglevod

    Dietary stearic acid induces mitochondrial fusion in humans. Relevance for ME/CFS?

    @Hip I think MP is mainly about more robust VDR activation compared to calcitriol. When immune cells are challenged with toxins (from growing/persistent infections) or as a result of antibiotics-induced toxemia, VDR expression spikes (due to stimulation of TLR receptors). As a result more...
  23. uglevod

    Need to Understand Lithium Dumping

    that's very interesting - do you have any references to read more on oxalates induced copper blockade? p.s. copper is important for immunity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521016/ https://pubs.acs.org/doi/10.1021/acsinfecdis.8b00171...
  24. uglevod

    Proper plasma levels of vitamin D to maximize NK cells function

    Keep in mind that everything comes at a price. In case of "Vit" D(secosteroid hormone), "NK maximizing" comes at a cost of monocytes/macrophages response inhibition from pathogen associated molecular patterns aka PAMPs stimulation - a shift from so called Th1 towards Th2.
  25. uglevod

    Dark Side of Vitamin A(retinol)

    Vitamin A Deficiency DOES NOT EXIST: "Vitamin A deficiency" doesn't exist and has never existed. What was called "Vitamin A deficiency" has always been deficiencies of OTHER nutrients in the diet. Animal studies and human studies, up to 2 years long, have shown NO problems with extremely low...
  26. uglevod

    Dark Side of Vitamin A(retinol)

    https://medium.com/@joshg99/i-believe-a-canadian-engineer-named-grant-genereux-has-discovered-the-primary-cause-of-auto-immune-d636d4e4b272 I believe a Canadian engineer named Grant Genereux has discovered the primary cause of auto-immune disease. He used his discovery to cure himself of...
  27. uglevod

    Dark Side of Vitamin A(retinol)

    Vitamin A supplementation may cause immune system to 'forget' past infections. https://www.sciencedaily.com/releases/2015/06/150630121406.htm Although vitamin A supplementation can have profound health benefits when someone is deficient, new evidence is emerging to show that vitamin A...
  28. uglevod

    What’s Up With Ivermectin?

    Ivermectin is unlikely to ever gain official approval because this is one of the few drugs that is able not only to treat, but also to cure a number of chronic diseases. Imagine a situation when iver passes into the category of a mass medicine even as a prophylactic agent and, unexpectedly...
  29. uglevod

    What’s Up With Ivermectin?

    IVERMECTIN based Covid19 Viral Therapy: "I CAN'T KEEP DOING THIS": Doctor pleads for review of data during COVID-19 Senate hearing: Covid-19: WHO-sponsored preliminary review indicates Ivermectin effectiveness: https://swprs.org/who-preliminary-review-confirms-ivermectin-effectiveness/
  30. uglevod

    Bad reaction high dose to vitamin D

    That's all so complex. Vit D as a vitamin is a direct antibacterial/antiviral. As a hormone it is additionally an inducer of antiviral/antibacterial peptides(given the fact that its effect is not already blocked by pathogens). I'd keep a close eye on the calcium levels in blood, since it could...