Search results

I know. The most effective way to get uridine is sublingual Uridine Mono-Phosphate (UMP). It seems to absorb well sublingually if the supp is not too old. In any case this deserves caution: uridine is not well understood and could have bad anti-metabolic effects if not taken properly. The safest...

There are some things I forgot, in case it helps someone. Along with those 3 ridiculous high dose substances (nobody takes them in those doses, believe me), I started mouthwashing with xylitol. I found it hard to believe it would do much, but after reading some studies I think it's plausible it...

I have significant health problems remaining, but no more ME/CFS symptoms at the moment. I was 98% sedentary (not bed-bound) for over 2.5 years, and for at least several months of time went through drug withdrawals. During those I took absurdly high doses of agmatine (3-6g+/day), theanine...

@joejack102 Shit I forgot. This was the reason I replied but haven't slept much for 4 days (it's 5am) so forgot about it writing the points: https://www.ncbi.nlm.nih.gov/pubmed/8051988 @alicec and others already alluded to it but that's a little more tangible idea (1g CDP, 30 days -> 1/2 blood...

@joejack102 Misc ideas for you (consider individually): 1. https://www.ncbi.nlm.nih.gov/pubmed/19372354 2. https://www.sciencedirect.com/science/article/pii/S0007091217335420 3. https://www.hindawi.com/journals/grp/2018/9252984/ 4. http://gut.bmj.com/content/48/1/125 5. If choline acted as an...

Note the amino supplements are really intended to work together with the methionine restriction. But some people don't eat that much protein or methionine to begin with, and theoretically the MTHFR/MTRR/IIRC mutation might lessen the need to restrict by some percent.

I don't know any research showing those genes having associations with weight gain. The general solution is specific amino acid restriction. Methionine restriction and BCAA restriction can have positive effects (BCAAs in blood correlate with obesity with some functional links [mice] [humans]...

I don't really want to post here, but I just wanted to point out, because this confuses the hell out of people and it's actively setting people back: methylation can in fact be tied to weight gain. A subset of people will notice direct effects from this. One thing that happens is that the liver...

Adreno isn't posting anymore. I'm starting to become drunk so I'm going to post in his place. He doesn't endorse me posting this. You basically can't prevent trytophan going down the kynurenine pathway. That basically amounts to curing the disease. You can lower it by lowering cortisol and...

http://raypeat.com/articles/articles/caffeine.shtml The most important roles for uridine are only coming out recently (https://www.sciencedaily.com/releases/2017/03/170317131617.htm) so it's impossible that he knew very much about it, so I wouldn't hold him as an authority on it anyway.

@joejack102 Sorry I'm under enough pressure/struggling that I can't follow forums anymore. To have problems from uridine you'd have to get high enough bloods levels to affect the brain in a negative manner, such that [less likely when not taken as sublingual UMP]. With CDP-choline you have to...

@Hip Thank you for describing your experience. I had a 50/50 bet I would react like that and couldn't afford to. I can't recall if this was discussed already, but in this context it's worth bringing up this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559110/ It's a landmark study on...

I only used bromantane for 1.5 weeks before stopping (pressures) so maybe a longer course. But stayed on adamantane for several months 5 days/week and beyond a week it stayed roughly the same. They're both impressive on paper, and expected bromantane to be stronger but got the opposite.

I tried bromantane but it was disappointingly weak in noticeable effects. In contrast I tried its parent chemical adamantane and it was much more potent and easy to overdo, both benefits and negatives (most notable were gut benefits though highly psychoactive good and bad). Supplement quality...

I was already "insensitive" to many things before choline. Herbs are useless or slightly negative to me. Overdoing choline definitely causes me several issues along that line. But the AI is ~500mg/day for men and too low hampers my cognition (I try get from egg yolks, the bitartrate appeared...

There's no simple way to put this. I'm a heavy choline and prior uridine user and I could not figure out acetylcholine receptors for my case chiefly because in the research they don't always behave like traditional receptors w.r.t. to up/downregulation, and there are at least 5 [muscarinic]...

The nootropics forums are littered with posts of terrible reactions to choline and uridine supplements (cdp-choline is prodrug for uridine, it depends how much/how you took it though it's less likely maybe) and nobody knows for sure. But a change in acetylcholine receptors is a common theme in...

That's the #1 thing (in queue) I'd like to see. Most of these things being posted are nice but mostly redundant one way or another.

Yeah I've had your problem for ages, nowadays I reserve some doses of opioids or phenibut for social occasions, they do work acutely, although I hate some aspects of phenibut. That still leaves daily life very bland especially since I stopped opioids during the week. In my case my best...

@Hip increased complex II activity one way or another is probably inevitable. Decreasing mTorC1 switches from lipogenic pathways to lipolytic (e.g. https://www.ncbi.nlm.nih.gov/pubmed/17142137 ) which depends on complex ii. It's reminiscent of muscle fiber reprogramming (ppar). Both the studies...

Thanks (I get similar tiredness/slight-stupid feeling from it and I'm not on rap). To be clear I wouldn't expect much out of any of these aminos without at least 4g single doses or more (for a couple weeks maybe), but I don't think you should do it with arginine anyway.

Yep, most of the time if something helps (my case) it turns out to be an opioid agonist in some study. I actually can't remember if kratom helped for this, either memory or I was too messed up. The other mainstream approach is 5-HT3 antagonists but they don't match up (for me). The only...

Exactly, I never take less than 6mg at once otherwise it's a waste of money. Maybe this study is speaking more than they intended it to, lol. Still, better to have options...

So this is apparently a mu- and kappa-opioid agonist (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874728/)? I could see myself resorting to this at some point provided it has truly minimal or no effects on the CNS (do not want kappa agonists there). I was hoping to see a trial to compare it...

That is a good point but I think it's several layers more complicated. For example the M1 vs M2 is a generalization, M2 is split into m2a/m2b/m2c and some studies show m2b has inflammatory properties and implicated in model of Lupus. In one of the more technical papers they characterize...

Well, mario linked this thread and this seems like where it should go (accidentally landed on this while searching for something unrelated, believe it or not): http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=17256&path%5B%5D=55230 (it doesn't...

Hi there I'm just curious, purely for my own information (not a suggestion), did you also try azithromycin?

@mariovitali Well thanks, but I'm not sure I can use that information myself at the present. I wasn't too aware that IL-6 had partial anti-inflammatory properties, but all of that might be muddled by the context which is atherosclerosis and other questions.

I don't remember seeing a thread here dedicated to listing them all. That would make an impressive resource. I have to do that all the time. I can tell you all these absorb topically to varying degrees: * vitamin d (20%?) - oil * niacinamide (90%?) - water spray - some other b vitamins may work...

For the record I ended up trying this with some 850nm LEDs on my neck/thyroid. I don't know if it was the pathway activation or thyroid itself acting up but it was strong enough that I had a mini crash for half a week from it. Maybe it hit lymph nodes or something I'm not aware of. It doesn't do...