Generally speaking, if a treatment is effective for ME/CFS, you will usually find it being employed by one or more of the leading ME/CFS specialist doctors. If you look at the list of treatments that these ME/CFS doctors use, it will typically be:
Oxymatrine, Epivir and more recently tenofovir for enterovirus-associated ME/CFS.
Valtrex, Famvir, Valcyte and cidofovir for herpesvirus-associated ME/CFS.
Other treatments that these doctors will use for ME/CFS include:
Low-dose naltrexone
IVIG
Ampligen
There are many further treatments as well that you can also explore, but the above are the main ones that have a good track record.