I take Thorne molybdenum. You may not be getting enough B1. What they put in complexes is just a guess for average people. I've found I need to individualize my Bs. If you need glutamine the Thorne powder is fine - too much can make you anxious. Most people tend to need glycine and NAC first, then glutamine.
I have NAC, but it seems to make me feel worse for some reason.
You're probably mobilizing some toxin and you're not able to eliminate it through your transsulfuration pathway (which moly and B1 support) and feces - need adequate fiber (vegetables) and water. If it can't get eliminated, it may be reabsorbed, giving you symptoms.
I thought methionine is part of the methylation cycle, if everything is fed? Forgive my ignorance.
No worries... It's in the methionine, or B12, cycle. It is used to make SAMe, and recycles homocysteine and vice versa. Most people have too much homocysteine, and need to feed the folate and methionine cycles to reduce it. A few people use up their homocysteine and can't recycle methionine, and run short of methionine (I'm one of them...)
I'm trying to avoid the methyl trap as described by Freddd. Maybe I am taking too much B12/5MTHF and it's causing too much booting up .
I've found there is no substitute for a good test to figure out what's going on. Saves a lot of guessing and mistakes. We are all individuals, with different genes, levels of toxicity, and other factors, like stress, infections, etc.
I do a Genova Diagnostics NutrEval every 9-12 months, which runs around $160 with their prepay program.
I never cease to be surprised at what I learn. I used to be extremely short of B6 until I cranked that up to 350mg daily, which is a huge amount. I need some glycine. I need folate, but usually need far more B12. I was short of moly and B1. And recently, I found I'm short of B2, not good if you want to make energy. And methionine, which most people don't need I've learned over time how to match my symptoms to my nutrient status and adjust, but its taken years.
Taking someone else's protocol is a recipe for disaster. You need to find what works for you.
Early on, I learned a lot from Amy Yasko and Dr. Roberts "Heartfixer." (Googelthem and methylation.) People will say they have errors in their info, but 10 years ago, when I started, there was less available, and they helped me with the basic concepts. Ben Lynch has gathered a lot of research together and has developed tools and YouTube videos. BeyondMTHFR has some good info, too.
Learning and understanding how the dynamics of methylation work will empower you to control your symptoms better. It won't cure ME/CFS, but its a foundation for your immune system, neurotransmitters, DNA replication, and energy production, and reduce your odds of cancer. It's important.
Good luck!