Hi guys,
I'm really struggling at the moment and would appreciate some input. My fatigue, exhaustion is horrendous, (aswell as usual symptoms) and my legs and arms so so heavy.
I've had CFS for almost 5 years now, and nothing has helped more than transiently.
Tests are as follows:
Mitochondrial dysfunction, low whole atp, low amp, poor recycling, low serum carnitine
Positive Elispot for Lyme, one month IV rochephin, no improvement in symptoms.
I have tried all the usual mitochondrial supplements, aceytl l carnitine, d ribose, coq10, ubiquinol etc and not so much as a glimmer of hope from them!
The only things which have helped, and then stopped (lack of cofactors?) have been:
L carnitine Fumarate. Decreased the heaviness and 'lactic acidy' feeling in my legs. For a day and then subsequent dosages nothing.
Armour Thyroid 1/2 grain. 30% more energy, not jittery, but normal energy within 2 hours. Contains 4.5mcg of t3 so must have been that, but stopped working after a few days. I didn't increase dose, had tests done and all my numbers were normal, within range. Ft3, ft4, tsh and rt3.
Ft3 was high normal, rt3 ratio was good. Tsh is always above 3+ and my temps rarely above 36.2c. I know t3 can have an effect on mitochondrial biogenesis but the result was so quick and dramatic, I'd be amazed if that was it.
Infra red sauna. After two days use, better grip strength and much less brain fog and clarity of vision but again stopped working after those two days (was supplementing with electrolytes etc) and now they make me feel rather ill.
For me, I am convinced my main issues are mitochondrial, and probably Krebs cycle related, or the electron transport chain not working. I can't afford a nutraeval test atm, but I'd be interested to see if any of you guys have an idea for example why the lcf stopped working, what co factor might be needed etc.
Thanks
I'm really struggling at the moment and would appreciate some input. My fatigue, exhaustion is horrendous, (aswell as usual symptoms) and my legs and arms so so heavy.
I've had CFS for almost 5 years now, and nothing has helped more than transiently.
Tests are as follows:
Mitochondrial dysfunction, low whole atp, low amp, poor recycling, low serum carnitine
Positive Elispot for Lyme, one month IV rochephin, no improvement in symptoms.
I have tried all the usual mitochondrial supplements, aceytl l carnitine, d ribose, coq10, ubiquinol etc and not so much as a glimmer of hope from them!
The only things which have helped, and then stopped (lack of cofactors?) have been:
L carnitine Fumarate. Decreased the heaviness and 'lactic acidy' feeling in my legs. For a day and then subsequent dosages nothing.
Armour Thyroid 1/2 grain. 30% more energy, not jittery, but normal energy within 2 hours. Contains 4.5mcg of t3 so must have been that, but stopped working after a few days. I didn't increase dose, had tests done and all my numbers were normal, within range. Ft3, ft4, tsh and rt3.
Ft3 was high normal, rt3 ratio was good. Tsh is always above 3+ and my temps rarely above 36.2c. I know t3 can have an effect on mitochondrial biogenesis but the result was so quick and dramatic, I'd be amazed if that was it.
Infra red sauna. After two days use, better grip strength and much less brain fog and clarity of vision but again stopped working after those two days (was supplementing with electrolytes etc) and now they make me feel rather ill.
For me, I am convinced my main issues are mitochondrial, and probably Krebs cycle related, or the electron transport chain not working. I can't afford a nutraeval test atm, but I'd be interested to see if any of you guys have an idea for example why the lcf stopped working, what co factor might be needed etc.
Thanks