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Roadblocks to Successful Methylation Treatment

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by caledonia, Mar 27, 2014.

  1. caledonia

    caledonia

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    Hi All,

    I've been working on this document for awhile, as these are common questions and situations which come up over and over.

    I've identified 17 roadblocks to successful methylation and how to get around them. I think I've run into most of them - lol. Hopefully others can benefit from my experience and the collective experiences of others.

    I have it geared towards ME/CFS patients - being super cautious so you don't make yourself worse - but anyone trying methylation treatment for whatever reasons should find it useful.

    7-22-2014 - I have added a new section regarding Lithium Deficiency and a few other minor changes.

    Attached Files:

    Last edited: Jul 22, 2014 at 3:26 PM
    Beyond, SeaShell, Lou and 8 others like this.
  2. helen1

    helen1 Senior Member

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    Spectacular document Caledonia. Thank you for your hard work on this.
  3. richarduklon

    richarduklon

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    a great document, though a lot to take in.
  4. Gondwanaland

    Gondwanaland

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    Thank you so much for sharing this, Caledonia. It is a little too late for me but I have lost the ability of planning ahead some years ago anyway LOL

    izzy
  5. PeterPositive

    PeterPositive Senior Member

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    Thanks, very well done.
  6. Myrtle

    Myrtle

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    Thank you, this is most useful.
    I have added this and some of your other documents (4R gut and start low go slow) to the documents I have put on this forum and printed them out and made a wiki which I have in a folder, I have found this very useful :)
  7. bootsydan

    bootsydan

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    I am about to embark on Methylation cycle, preluded by Fixing Gut Health.

    Due to the complicated ins and outs of Methylation I have been doing much research, and I find this document, along with your others as linked in this one, hugely helpful and informative.

    Thank you very much for taking the time to put it together. I for one am very grateful.

    I do have a few q's however and wonder if you can help me clarify?

    a) Everything I have read suggests reactions to methylation cycle are normal. So how do you know when the reaction is normal and you have nothing to worry about, vs when you need to start the CBS protocol?
    b) How long does CBS protocol take?
    c) Do you stop taking the core methylation cycle supplements when doing CBS?
    d) Is l-carntine fumarate something that should be considered core (along with MeCbl, AdoCbl & Methylfolate), is it something that should only be taken when the 3 core's are being well tolerated, or is it something that should be only taken when the 3 core's are not being well tolerated? My understanding on it's place in the cycle is hazy.

    Thanks a lot!
  8. caledonia

    caledonia

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    Heartfixer has the best info on how to tell if you need to treat it.

    I think about 2 months average. It took me 3 months.

    Technically since CBS is a First Priority mutation (going by Yasko theory), then you wouldn't have started any core supplements yet. Core supplements are Second Priority. This just means you do them second, it doesn't mean they're any less important.

    According to Freddd theory, l-carnitine fumarate (LCF) is a co factor which if you don't have it, may become a block to getting the methylation cycle going.

    I took LCF because Heartfixer suggested taking it if you had energy problems, and also the LCF part of my Kreb's cycle showed up blocked on my Nutreval test. I took it for many months, and it gave me a bit of much appreciated energy. Now with further healing, I don't need to take it anymore. After discontinuing it, my energy hasn't gone backwards, which I take as a good sign.
    helen1 likes this.
  9. bootsydan

    bootsydan

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    OK, so I gather this is determined by the tests... Without taking the tests much more guess work/luck is involved.

    Edit: The difference in cost between 23andme & NutrEval is about $700. Is the NutrEval really worth that much more?

    Also, given that Sulfate and Ammonia seem to be the two most important CBS factors tested for, might urine/blood tests of these be a decent money saving alternative?

    This is where I was getting confused. My interpretation was that you started CBS if Methylation was not working correctly. I didn't know it should be done before starting Methylation cycle. I guess both are possibly true, only I didn't understand the latter.


    Thanks for clearing that up!
    Last edited: Mar 29, 2014
  10. bootsydan

    bootsydan

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    Also, one last question:

    Given the 6-8 week "honeymoon" period, does this mean it is best not to increase dosages at all for at least 2 months, even if we are experience no negative reactions?
  11. ahmo

    ahmo Senior Member

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    @caledonia I've finally had a chance to view this. You've done a great job, a great service. Really well done! :balloons::balloons:Thanks, ahmo
  12. jepps

    jepps

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    Many thanks, caledonia, for this greatful document, and for posting it!!!! jepps
  13. caledonia

    caledonia

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    The Nutreval is a very comprehensive functional test. You can get an idea of what you can learn from the test by looking at the Nutreval Interpretation Guide linked in my signature.

    Yes. The "poor man's test" is to just use the urine sulfate strips.

    You could do it either way depending on your tolerance for experiencing adverse symptoms. I actually did it the first way by accident and experienced the classic stress/anxiety reaction. Then I had to go backwards and stop all methylation supplements until I had CBS resolved. Then I was able to proceed with methylation.
  14. caledonia

    caledonia

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    Yes, Start Low and Go Slow. It's a marathon, not a sprint. Once methylation gets cranking it's like a speeding train, just like I show in the Methylation Made Easy videos. There is lots of momentum and inertia (cellularly speaking) and it takes awhile to put on the brakes if you run into problems with overmethylation, metal detox, mood swings and so forth.
  15. Kfarming

    Kfarming

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    I have a question. I have this genetic testing done through Genova Diagnostics back in 2010. Yet the results weren't explain well enough to me nor was I put on a complete protocol. I struggle with Lyme disease, many of the co-infections, plus EBV, and MCS.

    Is there a place where I can find out more info on the results I got from this company?
  16. bootsydan

    bootsydan

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    @caledonia

    Thanks again for all your advice.
  17. Helen

    Helen Senior Member

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    Kfarming, If you could post the result of the test in a new thread I think you will get help.
  18. caledonia

    caledonia

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    @Kfarming Here is the sample report: http://www.gdx.net/core/sample-reports/Neuro-Genomic-Sample-Report.pdf
    It tests MTHFR C677T and A1298C, COMT V158M, GSMT1, GSTP1 A114V, SOD2 A16V (which is reported backwards as -/- being the bad one)

    So that's somewhat useful info, but it would be good to see VDR taq to help with COMT interpretation, MTR, MTRR, BHMT, CBS and so forth.

    Like Helen says, make a new post with your results and some people will likely stop by to interpret. If you want a particular person, like me or Valentijn, then type an @ sign and then their name like I did at the top of this thread for you. The person will get an alert to read your messge.
    place likes this.
  19. Uno

    Uno Senior Member

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    Thanks Caledonia this is excellent information.
  20. kimomile

    kimomile

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    This document is awesome! My ND is studying with Ben Lynch and said that I needed to deal with COMT before the MTHFR stuff. I wonder if this is newer information or maybe she just has it wrong. She said that in order to tolerate the methyls, we need to deal with COMT and MAO A. I also have VDR taq +/+.

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