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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Did you feel the effects the same day or did it take a while to build up?Methyfolate was a nightmare - I was already unwell from MB12, then Mfolate pushed me into acidosis and to a extremely low serotonin state. I assume the anxiety feeling was due to hypoglycemia.
Folinic wasn't a problem at all.
I think I took methylfolate no more than 4x and then the acidosis symptoms became unberable. I was taking 400mcg and then the last time I took it twice by mistake (800mcg).Did you feel the effects the same day or did it take a while to build up?
So you noticed some symptoms the first time you took it?I think I took methylfolate no more than 4x and then the acidosis symptoms became unberable. I was taking 400mcg and then the last time I took it twice by mistake (800mcg).
Yes, I did.So you noticed some symptoms the first time you took it?
BTW my husband took Mfolate 1x something like twenty or thirty micrograms and his serotonin plummeted.
Me neither, but I read explanations from knowleadgeable folks here saying that 1) too much serotonin will inhibit serotonin production and this inhibition has a lot of momentum and lasts for several weeks 2) Mfolate activity in the brain is opposed to a SSRI, i.e., it increases serotonin reuptake and then you are left with none by the mechanism (1).I am in no way knowledgable in biochemistry but wouldn't methylfolate increase Serotonin? I thought that's why it's successful with treatment resistant depression?
Extreme sadness in my and my husband's experience.What defines a low Serotonin state?