- Messages
- 27
- Location
- Florida West Coast, USA
I posted several months ago seeking assistance on an idiopathic symmetric sensorimotor stocking-glove axonal polyneuropathy. I’m 67; numbness started in feet four years ago. Over the years proprioception probs, ataxia, positive Romberg, leg weakness but no pain, slowly advancing numbness, thermal sensitivity compromised.
In Feb 2014, stopped CB-12 (B-12 deficiency discovered years earlier) and started MB-12 @ 5mg Kirkland. Dramatic results by the next day with improved walking, much less burning in calves. Continued improvement over 3 ½ months, numbness-free except for feet. I had my real legs back. Stability much improved. Able to tandem walk. Chronic neurotransmitter problems (depression, combat PTSD) began clearing. Was able to walk down all psych Meds over ensuing two month period. MB-12 increased. Methylfolate added to the mix.
In June 2014, numbness creeping back and more frequently quantum advancements, sometime moving inches up legs overnight, reaching waist, and forearms. But numbness would usually retreat unexpectedly after days or a week or so.
A recommendation from @Freddd (thanks!) during one of the numbness surges was a three-day regimen of LCF/MB-12/MB-9, AB-12, LCF/MB-12/MB-9 which stopped the sporadic rapidly advancing numbness. However, Subsequently, I was not reliably able to halt the fast-moving numbness each time.
Until now. I have found a clear cause and effect relationship that I did not expect. Taking my blood glucose numbers, I learned that the higher glucose reading (for me, approx 110-135 five hrs after eating) absolutely predicted sudden advancement of numbness within a day. Correspondingly, lower glucose numbers (80s) would indicate no discernible numbness increase.
Subclinical diabetes you say? Current neuro says No, and “no clinician will prescribe (diabetes) Meds” with my numbers (typically 90-95, A1C 5.5). EMG/NCVs have been variously interpreted as possibly diabetes, certainly not diabetes.
Recently, a new symptom: vision fuzziness and shimmery, wavy lines in part of left eye. Optho guy says more indicative of MS than diabetes but an LP two years ago showed no oglio bands.
Further, I have learned that I can affect the advancing numbness (but with less precision than sugarless diet) with larger doses of methylfolate alone. A shot of MB-9 after a high glucose reading will usually bring the number (and numbness) down within 12-18 hours, otherwise high for a couple of days.
My current thinking is that this is a cellular Sorbitol buildup in the glucose processing pathway but I wanted to get experienced eyes on this, especially considering the new data on the blood glucose/numbness relationship.
In Feb 2014, stopped CB-12 (B-12 deficiency discovered years earlier) and started MB-12 @ 5mg Kirkland. Dramatic results by the next day with improved walking, much less burning in calves. Continued improvement over 3 ½ months, numbness-free except for feet. I had my real legs back. Stability much improved. Able to tandem walk. Chronic neurotransmitter problems (depression, combat PTSD) began clearing. Was able to walk down all psych Meds over ensuing two month period. MB-12 increased. Methylfolate added to the mix.
In June 2014, numbness creeping back and more frequently quantum advancements, sometime moving inches up legs overnight, reaching waist, and forearms. But numbness would usually retreat unexpectedly after days or a week or so.
A recommendation from @Freddd (thanks!) during one of the numbness surges was a three-day regimen of LCF/MB-12/MB-9, AB-12, LCF/MB-12/MB-9 which stopped the sporadic rapidly advancing numbness. However, Subsequently, I was not reliably able to halt the fast-moving numbness each time.
Until now. I have found a clear cause and effect relationship that I did not expect. Taking my blood glucose numbers, I learned that the higher glucose reading (for me, approx 110-135 five hrs after eating) absolutely predicted sudden advancement of numbness within a day. Correspondingly, lower glucose numbers (80s) would indicate no discernible numbness increase.
Subclinical diabetes you say? Current neuro says No, and “no clinician will prescribe (diabetes) Meds” with my numbers (typically 90-95, A1C 5.5). EMG/NCVs have been variously interpreted as possibly diabetes, certainly not diabetes.
Recently, a new symptom: vision fuzziness and shimmery, wavy lines in part of left eye. Optho guy says more indicative of MS than diabetes but an LP two years ago showed no oglio bands.
Further, I have learned that I can affect the advancing numbness (but with less precision than sugarless diet) with larger doses of methylfolate alone. A shot of MB-9 after a high glucose reading will usually bring the number (and numbness) down within 12-18 hours, otherwise high for a couple of days.
My current thinking is that this is a cellular Sorbitol buildup in the glucose processing pathway but I wanted to get experienced eyes on this, especially considering the new data on the blood glucose/numbness relationship.