Hello - I’m struggling to interpret the results / treatment implications for a couple tests my CFS doctor recently ordered. I’ve searched the forums and poked around the internet but, not surprisingly, I remain confused. I’d be super appreciative if some of you learned folks could provide feedback.
#1…B12 Unsaturated Binding Capacity test. The result came back <300 (reference range 725 – 2045). Unfortunately the doctor didn’t provide a great explanation for what this result indicates and I couldn’t find much discussion elsewhere. Does this result tell me anything about my ability to utilize all forms of supplemented B12? Based on this result the doctor is considering recommending high dose injected methylB12 (up to 25 mg daily).
Regarding the test itself…the lab required 72 hours without B12 supplements prior to the test – I don’t know if the test protocol assumes the patient would have been using cyanocobalamin supplements. I have been supplementing with 5000mcg sublingual methylB12 and occasional adB12 for the last year. Any idea whether that would have skewed the test results?
#2…I also got results of a COMT genetic test showing I am heterozygous (Val158/Met158). I’ve come across various postings / commentary that seem to conflict as to whether supplementing with methylB12 and methylfolate are problematic or beneficial. Any thoughts? Also, I can't find much in the way of treatment protocols designed to overcome the COMT enzyme deficiency. Can anyone point me toward treatment discussions?
As background…I am homozygous 677TT for MTHFR.
Thanks so much for your input! Dan
#1…B12 Unsaturated Binding Capacity test. The result came back <300 (reference range 725 – 2045). Unfortunately the doctor didn’t provide a great explanation for what this result indicates and I couldn’t find much discussion elsewhere. Does this result tell me anything about my ability to utilize all forms of supplemented B12? Based on this result the doctor is considering recommending high dose injected methylB12 (up to 25 mg daily).
Regarding the test itself…the lab required 72 hours without B12 supplements prior to the test – I don’t know if the test protocol assumes the patient would have been using cyanocobalamin supplements. I have been supplementing with 5000mcg sublingual methylB12 and occasional adB12 for the last year. Any idea whether that would have skewed the test results?
#2…I also got results of a COMT genetic test showing I am heterozygous (Val158/Met158). I’ve come across various postings / commentary that seem to conflict as to whether supplementing with methylB12 and methylfolate are problematic or beneficial. Any thoughts? Also, I can't find much in the way of treatment protocols designed to overcome the COMT enzyme deficiency. Can anyone point me toward treatment discussions?
As background…I am homozygous 677TT for MTHFR.
Thanks so much for your input! Dan