Supplements and Drugs That Fix A Leaky Gut:
Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Ref:
1.
Zinc carnosine supplement helps prevent leaky gut occurring. Ref:
1.
Colostrum is a powerful means to repair laky gut. In a study on indomethacin-induced gut hyperpermeability, bovine colostrum was able to counter the leaky gut produced by indomethacin (which is an NSAID drug). Ref:
1.
Triphala herbal formula (especially the
Emblica officinalis component, aka "Indian gooseberry") protects against methotrexate-induced intestinal permeability in rat intestine. Ref:
1.
Glutamine supplementation decreases intestinal permeability and preserves gut mucosa integrity in an experimental mouse model. Ref:
1.
Curcumin may help decrease intestinal permeability, and may work well with glutamine. Ref:
1.
Probiotic bacteria might be beneficial in protecting intestinal epithelial cells from the deleterious effects of pathogenic bacteria. Ref:
1.
Slippery elm bark (Ulmus fulva) may help reduce intestinal permeability. Ref:
1.
Berberine attenuates disruption of tight junctions in the intestinal epithelium in a mice model of endotoxinemia. This may possibly have been mediated through down-regulation of NF-kB and myosin light chain kinase pathway. Ref:
1.
Low-dose sulfasalazine (500 mg once or twice a day) prevents tight junction disruption induced by TNF-alpha. Ref:
1. Note that the drug sulfasalazine is a potent inhibitor of NF-κB activation, and TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation, so this explains how sulfasalazine can reduce leaky gut. Ref:
1.