Journeyman
Senior Member
- Messages
- 193
Hi Folks,
I understand that NutraHacker is frowned upon somewhat for its alleged inaccuracies, but I can't help but notice a lot of its interpretations are correct and thus useful for implementing solutions to SNP polymorphisms.
I recently used its report for the first time to analyse my old V3 23 & Me results and my attention was drawn to the red tab (homozygous mutation?) for rs1801131. This is new for me and I read with interest the 'Consequences' and 'Encourage' and 'Avoid' tabs for rs1801131 where apparently I've got a RED 0.0071% mutation that relates to my conversion of folic acid to 5-MTHF.
Now from what I understand rs1801131 is another way of describing the A1298 SNP, however my genetic genie results only indicated that I was heterozygous for that SNP so what is the SNP that rs1801131 relates to and if it is A1298 as I suspect, then why is Nutrahacker indicating I'm homozygous for the mutation where as Genetic Genie is indicating just heterozygous...?
It says that one of the key consequences of this rs1801131 mutation is low BH4 which might be more significant for me since I already have a mutation for BH8??? with the implication being lower serotonin (might explain the anxiety??)
However it also mentions that it results in excess Ammonia. Now I always assumed that since I don't have a CBS mutation I would have no ammonia issues. How significant is the 'ammonia' effect of this polymorphism??
It also indicates decreased glutathione which taking into account my absent GSTT1 SNP and hetero SOD2 means I'm at great risk of toxicity issues? (from the lack of glutathione) Which kinds of toxicities should I be looking to fight off here?? What might be the best way to do that (Glutathion supplementation??)
What does 'high sulfate' and higher 'ammonia' risk translate to in terms of diet noting I eat a lot of cruciferous vegetables (and fruit generally) and also noting the alleged consequence of 'poor conversion of folic acid to 5-MTHF. Is it referring to the synthetic folate or the folate I'd be getting from the high amount of fruit/vegs I'm eating....
Any clarification on these points would be most appreciated and I've upped the nutrahacker report in case you can see any other things that might tie together that I should be aware of!
Regards
Journeyman
I understand that NutraHacker is frowned upon somewhat for its alleged inaccuracies, but I can't help but notice a lot of its interpretations are correct and thus useful for implementing solutions to SNP polymorphisms.
I recently used its report for the first time to analyse my old V3 23 & Me results and my attention was drawn to the red tab (homozygous mutation?) for rs1801131. This is new for me and I read with interest the 'Consequences' and 'Encourage' and 'Avoid' tabs for rs1801131 where apparently I've got a RED 0.0071% mutation that relates to my conversion of folic acid to 5-MTHF.
Now from what I understand rs1801131 is another way of describing the A1298 SNP, however my genetic genie results only indicated that I was heterozygous for that SNP so what is the SNP that rs1801131 relates to and if it is A1298 as I suspect, then why is Nutrahacker indicating I'm homozygous for the mutation where as Genetic Genie is indicating just heterozygous...?
It says that one of the key consequences of this rs1801131 mutation is low BH4 which might be more significant for me since I already have a mutation for BH8??? with the implication being lower serotonin (might explain the anxiety??)
However it also mentions that it results in excess Ammonia. Now I always assumed that since I don't have a CBS mutation I would have no ammonia issues. How significant is the 'ammonia' effect of this polymorphism??
It also indicates decreased glutathione which taking into account my absent GSTT1 SNP and hetero SOD2 means I'm at great risk of toxicity issues? (from the lack of glutathione) Which kinds of toxicities should I be looking to fight off here?? What might be the best way to do that (Glutathion supplementation??)
What does 'high sulfate' and higher 'ammonia' risk translate to in terms of diet noting I eat a lot of cruciferous vegetables (and fruit generally) and also noting the alleged consequence of 'poor conversion of folic acid to 5-MTHF. Is it referring to the synthetic folate or the folate I'd be getting from the high amount of fruit/vegs I'm eating....
Any clarification on these points would be most appreciated and I've upped the nutrahacker report in case you can see any other things that might tie together that I should be aware of!
Regards
Journeyman