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SNPs for Dihydrofolate Reductase (DHFR)

Discussion in 'Genetic Testing and SNPs' started by nandixon, Sep 25, 2012.

  1. Bluebell

    Bluebell More % Neanderthal than Adreno but less hairy :-D

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    Valentijn, I believe that you misunderstood what NanDixon said about Richvank's results.

    You have indicated in your table here that Rich's result for rs1650697 was AA. However, that is what NanDixon said HER result was. She stated that rs1650697 was the only one where she differed from Rich's.

    She also stated that Rich's results were all homozygous and all "-/-", so that probably means that Rich's result on rs1650697 was GG, the only other possibility if NanDixon's "+/+" AA homozygous result was different from his.

    In her original post, she wrote: "....his results appear to be completely normal (homozygous -/- throughout). Mine are identical to his with only one exception: the SNP rs1650697 (aka C35T or G-437A) that overlaps with a coding region for the gene MSH3 is homozygous (+/+) for the variant alleles (AA)....
    Below are my results for people to compare to theirs.... rs1650697 AA (+/+)."

    I have not tried to search for the thread where Rich reported his original 23andme results, but that would be the best way to make sure, of course. :)
    Valentijn likes this.
  2. Bluebell

    Bluebell More % Neanderthal than Adreno but less hairy :-D

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    Sea, I also have a CT at rs10072026, just like you --
    and otherwise, like you, I match Rich's results
    (if NanDixon was saying that Rich's rs1650697 was GG -- see the preceding post I made about that rs number -- which is also my result on that one, GG).

    As far as I can tell on DBsnp, the CT at rs10072026 was in about 20% of a European sample, but was not very common in other samples of ethnic groups that are listed there.
    Sea likes this.
  3. Bluebell

    Bluebell More % Neanderthal than Adreno but less hairy :-D

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    For the past couple of months, I've been struggling to drink 1 or 2 cups of green tea a day (I find the taste unpleasant, even when I mask it in a brew of other types of tea) and I don't think I feel better on any health dimension from drinking it (although I can't know what it might be doing internally-fighting potential cancer etc.), and when I applied it to my face as a toner once daily over 2 days, it stung and dried out my skin, so I'm not sure that green tea is for me. I would like to stop drinking it... I've read such overwhelmingly-positive reports of its health-giving properties that I was interested to learn here that it inhibits the production of BH4 (via DHFR). Yesterday I read that it reduces the absorption of thiamin (B1) and folate (B9), plus of course iron.
  4. nandixon

    nandixon Senior Member

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    That's right. The post where Rich gave his SNPs for DHFR is located here:
    http://forums.phoenixrising.me/inde...ies-please-post-here.14115/page-2#post-233836
    Valentijn likes this.
  5. roxie60

    roxie60 Senior Member

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    Central Illinois, USA
    Mine are the same as Nan's except for the last one I am AG which means I am exactly the same as Drex. I look forward to the GCH1 thread.....if it already exists can someone add the link plz
  6. ukxmrv

    ukxmrv Senior Member

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    London
    Here's mine but I am late to this thread and don't have a clue what it all means

    rs7387 TT
    rs1643659 TT
    rs1677693 GG
    rs1643649 TT
    rs11951910 TT
    rs865646 GG
    rs13161245 --
    rs10072026 TT
    rs11490741 CC
    rs863215 CC
    rs1478834 CC
    rs1650697 AG
  7. LynnD

    LynnD

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    Mine are the same as Val's.
    Anyone try food or supplements to see if beneficial for this snp's?
  8. trollo

    trollo Senior Member

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    Italy
    These are mine:

    rs7387 A or T AT (+/-)
    rs1643659 C or T CT (+/-)
    rs1677693 G or T GT (+/-)
    rs1643649 C or T CT (+/-)
    rs11951910 C or T TT (-/-)
    rs865646 G or T TT (+/+)
    rs13161245 A or G no call
    rs10072026 C or T TT (-/-)
    rs11490741 C or T CC (-/-)
    rs863215 C or T CT (+/-)
    rs1478834 A or C AC (+/-)
    rs1650697 A or G GG (-/-) p.s i corrected this as Valentjin made me do a mistake...

    Please can somebody explain to me what that means?? Does this mean i could have low BH4 recicling via DHFR??
    Last edited: Apr 18, 2014
  9. trollo

    trollo Senior Member

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    Italy
    But i yet haven't understood if there are any known deleterious DHFR snps already linked with issues by studies.
    Last edited: Apr 19, 2014
  10. aquariusgirl

    aquariusgirl Senior Member

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    Hmm, why would my mom only have 5 snps on that gene?
  11. Valentijn

    Valentijn Activity Level: 3

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    Amersfoort, Netherlands
    Newer chip?

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