Hi
@MartinDH ,
Going back on this switching from Psoriasis to ME and vice versa via a switch in T lymphocytes, I found a recent paper that gives a bit more informations about it:
"
Human Tregs appear metabolically flexible, switching between glycolysis-only and both glycolysis and fatty acid oxidation upon activation (
36).
In addition to providing energy for cell survival and division,
the choice between utilizing glycolytic and oxidative metabolism defines the lineage decision between Th17 cells and Tregs, respectively (
13) (reviewed in ref.
37).
The decision to oxidize fatty acids for OXPHOS is taken by Tregs in addition to memory T cells (
14) and is influenced by nutrient status, via mTOR and AMPK activation as well as pyruvate dehydrogenase kinase 1 (PDHK1) activation, Acetyl-CoA carboxylase 1 (ACC1) expression (
13,
14), and PTEN activity (
38,
39)"
So when T cell choose glycolytic metabolism, it matures into Th17 cells (associated with Psoriasis in your case)
and when T cell chose oxidative metabolism, it matures into Treg cells (expressing FOXP3 but with impaired activity which lead to ME)
It seems that
Cimetidine (anti acid drug) can do this switch but you have to pay attention to possible side effects, because a trial was done on psoriasis patients and two of them had side effects.