The CFS/ME puzzle...
I think Fred Davis is on point with regards to methylation. RichVank did understand that there was more to this syndrome than just a methylation block and glutathione depletion.
The missing link to CFS/ME puzzle in my opinion is Hypochlorhydria / Dysbiosis and the domino affects goes on and on and on. I also believe we have a weak liver genotype that contributes to these matrix of deficiencies. Yes we have a disease my friends, that not only damages the mitochondria cells. It also affects the kidney, brain and liver as well.
Hypochlorhydria + Dysbiosis = Acquired Mitochondrial Disease
Hydrochloric acid insufficiency could be the main contributing factor to the bacteria over-growth we are seeing and dramatically reduce stomach acid production. I believe we have genetic factors as well as environmental issues that make us vulnerable to this illness.
Can Helicobacter pylori cause low stomach acid?
H-pylori is a deep rooted infection that is very hard to eradicate. H-pylori can lead to a Gastritis inflammation of the stomach lining that can also develop into hypochlorhydria that can deplete the stomach ability to produce hydrochloric acid. We need stomach acid to protect and heal and repair the body. The research I have done has pointed to poor liver function and low stomach acid as risk factors in many chronic illnesses we see today.
Can Hypochlorhydria / HCL insufficiency be related to silent organ damage?
I am convinced that the toxic waste produced by the dysbiosis imbalance can be very damaging, especially when we are not methylating RNA, DNA and phosphatidylcholine. HCL insufficiency can cause minerals and lipids to be deficient. Also, manganese, zinc and choline are essential for the health of the liver and the mitochondria function. The body needs (HCL) to achieve the correct (pH) flora balance. Stomach acid is also required to liberate vitamin B12 from food. There are also many genetic variations that contribute to the liver detoxification capacity that could be a factor.
Radio: What can cause the Hypochlorhydria problem?
Hypochlorhydria?
Stomach acid assessment
http://www.drdebe.com/self-tests/stomach-acid-assessment
Salivary test for Hypochlorhydria
http://drmyhill.co.uk/wiki/Vascular_endothelial_growth_factor_(VEGF)-_salivary_test_for_hypochlorhydria
Hypochlorhydria lack of stomach acid - can cause lots of problems
http://drmyhill.co.uk/wiki/Hypochlorhydria_-_lack_of_stomach_acid_ _can_cause_lots_of_problems
Hypochlorhydria: A Review, parts 1 & 2
http://drmanlove.com/diet-and-nutrition-articles/low-stomach-acid.html
Gastritis / Wiki
http://en.wikipedia.org/wiki/Gastritis
Atrophic gastritis
http://en.wikipedia.org/wiki/Atrophic_gastritis
Radio: How can we test for gastritis?
Radio: What are H.Pylori main symptoms?
Radio: How can H.pylori damage the body?
Radio: Can H.pylori cause mineral depletion?
Get the right H. pylori test
http://www.ulcer-cure.com/index.php/h-pylori/all-about-h-pylori/getting-an-accurate-h-pylori-test
Radio: How can H.pylori affect the biochemical process in the body?
Helicobacter Wiki
http://en.wikipedia.org/wiki/Helicobacter_pylori
Radio: What is stomach acid role in beneficial bacteria?
Radio: Can gut micro-imbalances contribute to liver disease?
The Intestinal Microbiota and Liver Disease
http://www.nature.com/ajgsup/journal/v1/n1/full/ajgsup20123a.html
The-gut-microbiota-and-the-liver pdf
http://doctorsonly.co.il/wp-content/uploads/2013/05/The-gut-microbiota-and-the-liverjhep5.13.pdf
Radio: Can a choline deficiency contribute to fatty liver disease?
Radio: Please check out this diagram
http://www.nature.com/nrgastro/journal/v7/n12/fig_tab/nrgastro.2010.172_F1.html
Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/
CFS-me-as-a-liver-issue
http://forums.phoenixrising.me/index.php?threads/cfs-me-as-a-liver-issue.18776/
Radio: Is there a silent liver disease connection?
Radio: A bacterial overgrowth can also produce histamine, hydrogen sulfide, hydrogen peroxide, tryptophanase, d-lactic acid and endotoxins. This could be a possible contributing factor to the acquired mitochondrial disease and silent organ damage.
Fatty liver
http://en.wikipedia.org/wiki/Fatty_liver
Non-alcoholic Fatty Liver Disease
http://en.wikipedia.org/wiki/Non-alcoholic_fatty_liver_disease
Downregulation of Hepatic Glucose-6-Phosphatase-α in Patients With Hepatic Steatosis
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.118/full
Detoxification (The Liver)
http://www.gilbertssyndrome.com/detoxification.php
How-I-Recovered-From-CFS-part 2
http://forums.phoenixrising.me/index.php?threads/how-i-recovered-from-cfs-part-2.28684/
I think Fred Davis is on point with regards to methylation. RichVank did understand that there was more to this syndrome than just a methylation block and glutathione depletion.
The missing link to CFS/ME puzzle in my opinion is Hypochlorhydria / Dysbiosis and the domino affects goes on and on and on. I also believe we have a weak liver genotype that contributes to these matrix of deficiencies. Yes we have a disease my friends, that not only damages the mitochondria cells. It also affects the kidney, brain and liver as well.
Hypochlorhydria + Dysbiosis = Acquired Mitochondrial Disease
Hydrochloric acid insufficiency could be the main contributing factor to the bacteria over-growth we are seeing and dramatically reduce stomach acid production. I believe we have genetic factors as well as environmental issues that make us vulnerable to this illness.
Can Helicobacter pylori cause low stomach acid?
H-pylori is a deep rooted infection that is very hard to eradicate. H-pylori can lead to a Gastritis inflammation of the stomach lining that can also develop into hypochlorhydria that can deplete the stomach ability to produce hydrochloric acid. We need stomach acid to protect and heal and repair the body. The research I have done has pointed to poor liver function and low stomach acid as risk factors in many chronic illnesses we see today.
Can Hypochlorhydria / HCL insufficiency be related to silent organ damage?
I am convinced that the toxic waste produced by the dysbiosis imbalance can be very damaging, especially when we are not methylating RNA, DNA and phosphatidylcholine. HCL insufficiency can cause minerals and lipids to be deficient. Also, manganese, zinc and choline are essential for the health of the liver and the mitochondria function. The body needs (HCL) to achieve the correct (pH) flora balance. Stomach acid is also required to liberate vitamin B12 from food. There are also many genetic variations that contribute to the liver detoxification capacity that could be a factor.
Radio: What can cause the Hypochlorhydria problem?
See more at: Hypochlorhydria / Wiki
- The slowing of the body's basal metabolic rate associated with hypothyroidism
- Autoimmune disorders where there is antibody production against parietal cells which normally produce gastric acid.
- The use of antacids or drugs that decrease gastric acid production (such as H2-receptor antagonists) or transport (such as proton pump inhibitors).
- A symptom of rare diseases such as mucolipidosis (type IV).
- A symptom of Helicobacter pylori infection which neutralizes and decreases secretion of gastric acid to aid its survival in the stomach.[1]
- A symptom of pernicious anemia, atrophic gastritis or of stomach cancer.
- Radiation therapy involving the stomach.
- Gastric bypass procedures such a duodenal switch and RNY, where the largest acid producing parts of the stomach are either removed, or blinded.
- VIPomas (vasoactive intestinal peptides) and somatostatinomas are both islet cell tumors of the pancreas.
- Pellagra, caused by niacin deficiency.
http://en.wikipedia.org/wiki/Achlorhydria
Hypochlorhydria?
Stomach acid assessment
http://www.drdebe.com/self-tests/stomach-acid-assessment
Salivary test for Hypochlorhydria
http://drmyhill.co.uk/wiki/Vascular_endothelial_growth_factor_(VEGF)-_salivary_test_for_hypochlorhydria
Hypochlorhydria lack of stomach acid - can cause lots of problems
http://drmyhill.co.uk/wiki/Hypochlorhydria_-_lack_of_stomach_acid_ _can_cause_lots_of_problems
Hypochlorhydria: A Review, parts 1 & 2
http://drmanlove.com/diet-and-nutrition-articles/low-stomach-acid.html
Gastritis / Wiki
http://en.wikipedia.org/wiki/Gastritis
Atrophic gastritis
http://en.wikipedia.org/wiki/Atrophic_gastritis
What is Atrophic Gastritis?
Atrophic gastritis (AG) is a condition that develops when the stomach’s lining has been inflamed for many years. The inflammation is most often caused by an infection of the bacterium H. pylori. The infection gradually destroys cells in your stomach lining. It is thought that the bacteria cause inflammation by disrupting the barrier of mucus that protects your stomach lining from the acidic juices that help it digest food. Less often, AG occurs because your immune system mistakenly attacks the cells in your stomach lining. This is known as autoimmune atrophic gastritis. See more at: http://www.healthline.com/health/atrophic-gastritis#Description
Radio: How can we test for gastritis?
Using a scope to examine your upper digestive system (endoscopy). During endoscopy, your doctor passes a hollow tube equipped with a lens (endoscope) down your throat and into your esophagus, stomach and small intestine. Using the endoscope, your doctor looks for signs of inflammation. If a suspicious area is found, your doctor may remove small tissue samples (biopsy) for laboratory examination. See more at: http://www.mayoclinic.org/diseases-conditions/gastritis/basics/tests-diagnosis/con-20021032
Radio: What are H.Pylori main symptoms?
Many people with Helicobacter pylori bacteria have no outright symptoms which might be typical of H-Pylori, such as abdominal pain or ache, nausea, vomiting, frequent belching, or weight loss. Others may have symptoms that are more subtle, causing dysfunction of other functions of the body.
Helicobacter Pylori: Not Just A Third World Problem? http://www.stopthethyroidmadness.com/h-pylori/
Radio: How can H.pylori damage the body?
Damage it can cause include:
Absorption issues, Food allergies/sensitivities, Seasonal Allergies, Vitamin and mineral deficiencies, especially: B12, iron, vitamin D, lactoferrin, Autoimmune issues, Fatigue, Adrenal stress, Lowered thyroid hormone conversion, Elevated Histamine levels, Chronic infection, Parasites.
Low stomach acid
Ketosis, Neurotransmitter imbalance, including GABA, Liver and Gallbladder issues
Peptic UlcerCancers of the stomach, liver or cervix
Teeth and sinus problems
Cancers of the stomach, liver and cervix
Teeth and sinus problems
Additionally, h-pylori can cause the following problems:
http://www.ncbi.nlm.nih.gov/pubmed/9207257
- H. pylori lowers Stomach Acid:
http://www.healingnaturallybybee.com/articles/dig10.php
http://www.ncbi.nlm.nih.gov/pubmed/15285524
- H. pylori impairs Iron Absorption:
Coincidentally, lactoferrin supplements can help eradicate H.pylori and raise iron levels as well.
http://www.ncbi.nlm.nih.gov/pubmed/14620619
http://www.healthyfellow.com/309/lactoferrin-and-anemia/
Stopthethyroidmadness.com/h-pylori
http://www.stopthethyroidmadness.com/h-pylori/
Radio: Can H.pylori cause mineral depletion?
H-pylori can block the absorption minerals and neutralizing stomach acids. The body has a preference for minerals. For example, the body prefers Zinc for over 50 critical enzymes. However, if Zinc becomes deficient (which is very common) or exposure to Cadmium, Lead or Mercury is sufficiently high, the body will use these toxic minerals in place of Zinc. When H. pylori infection decided to make a home in your body, it needs certain materials to do that. It needs to neutralize acid. It needs certain vitamins (B-12 is one of them). It needs to make enzymes to help keep it alive, its enzymes use up manganesm leaving the body deficient in manganese. Manganese is needed to fight free radicals. Without it cell membranes and the DNA are damaged. - See more at: http://www.mygutsy.com/is-h-pylori-...sorders-adrenal-fatigue/#sthash.1KzwEYym.dpuf
Get the right H. pylori test
http://www.ulcer-cure.com/index.php/h-pylori/all-about-h-pylori/getting-an-accurate-h-pylori-test
Radio: How can H.pylori affect the biochemical process in the body?
If you don’t know anything about h. pylori I suggest you watch these video’s. I have done lots of research over the past months and these videos are very detailed and explain the biochemical process your body goes through and what the h. pylori does (what vitamins it takes away, detox pathways it ruins, etc..) to the body. I wont lie- they are long, but if you are serious about eradicating the h.pylori for good, then you need to know your facts.
h. pylori- another piece to the puzzle
h. p- part 2
I find Dr. Amy is a very thorough Dr. and researcher and her protocol and testing techniques actually work. Here is her site.
See more about H-pylori info at, http://www.mygutsy.com/is-h-pylori-...sorders-adrenal-fatigue/#sthash.1KzwEYym.dpuf
Helicobacter Wiki
http://en.wikipedia.org/wiki/Helicobacter_pylori
Radio: What is stomach acid role in beneficial bacteria?
In order for any pathogen to enter your small intestine via the stomach it has to survive stomach acid. Stomach or hydrochloric acid is there to not only begin the digestion of protein, but to kill any pathogens ingested with food or present in saliva before they take up residence in your gut and cause dysbiosis. At a pH of 4, most bacteria are killed within 30 minutes, but the pH of a normal human stomach is an even more acidic 2. That means that 99% of bacteria are killed within 5 minutes of entering the stomach. This is why relying on yogurt or kefir to quickly repopulate your gut with beneficial bacteria isn’t going to happen. If it did, you would have much bigger problems.
Therefore, it follows that anything that compromises this very important gastric barrier is going to predispose you to SIBO.
Other causes of impaired gastric barrier function include H. pylori infection, malnutrition and various autoimmune diseases like pernicious anemia. Gastric surgeries like gastrectomy (partial or full removal of the stomach) and truncal vagotomy (resection of the vagus nerve) can also cause SIBO by either raising stomach pH, preventing its production or impairing motility.
Small-intestinal-bacterial-overgrowth
http://syontix.com/small-intestinal-bacterial-overgrowth-part-three-gastric-barrier-dysfunction/
Radio: Can gut micro-imbalances contribute to liver disease?
Microbes that reside in colons of obese individuals produce many compounds that could contribute to development of non-alcoholic fatty liver disease (NAFLD) and other complications of obesity, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.
Microorganisms living in the human intestine (gut microbiota) affect digestion, energy metabolism, inflammatory signaling pathways, and even liver function. Changes in the gut microbiota have been associated with obesity, diabetes, metabolic syndrome, and liver disease. The microbiota of obese individuals has been reported to have less diversity and altered concentrations of specific types of microbes, compared with lean individuals.
Chronic excessive ingestion of ethanol produces liver steatosis, steatohepatitis, and cirrhosis. Gut microbes are an endogenous source of ethanol, which can be continuously delivered to the liver. The microbes also produce about 300 other volatile organic compounds (VOCs), but little is known about their effects on liver or other organs.
How Can the Gut Microbiota Contribute to Liver Disease?
http://agajournals.wordpress.com/2013/07/08/how-can-the-gut-microbiota-contribute-to-liver-disease/
The Intestinal Microbiota and Liver Disease
http://www.nature.com/ajgsup/journal/v1/n1/full/ajgsup20123a.html
The-gut-microbiota-and-the-liver pdf
http://doctorsonly.co.il/wp-content/uploads/2013/05/The-gut-microbiota-and-the-liverjhep5.13.pdf
Radio: Can a choline deficiency contribute to fatty liver disease?
Does choline play the same role in fatty liver disease in humans? There are a few reasons to think it does. The most convincing of these is that it's been demonstrated in folks getting fed intravenously. The most interesting of these is the wide prevalence of a defect in the gene that allows us to synthesize phosphatidylcholine from the amino acid methionine. Its prevalence is high in the general population but almost complete among those with fatty liver.
The basic mechanisms of fatty liver in humans are the same as they are in animals. Humans with fatty liver disease have increased lipogenesis (synthesis of fat from carbohydrate) (1), increased circulation of fat released from adipose tissue (2), and decreased secretion of fat from the liver (3).
Although folks with fatty liver release more fatty acids from the fat tissue, the studies cited above show that their livers don't actually synthesize more fat from these fatty acids than the livers of healthy folks do. So those fatty acids may contribute to "lipotoxicity" -- and in fact the creation of triglycerides in the liver is in part probably an effort to protect against the toxicity of excess free fatty acids -- but it seems that the synthesis of fat from carbohydrate is more important than the release of fat from adipose stores.
Continue reading at....
Does Choline Deficiency Contribute to Fatty Liver in Humans
http://blog.cholesterol-and-health.com/2010/11/does-choline-deficiency-contribute-to.html
Radio: Please check out this diagram
http://www.nature.com/nrgastro/journal/v7/n12/fig_tab/nrgastro.2010.172_F1.html
Phosphatidylcholine / Lipid (fat) transport and metabolism
Fat and cholesterol consumed in the diet are transported to the liver by lipoproteins called chylomicrons. In the liver, fat and cholesterol are packaged into lipoproteins called very low density lipoproteins (VLDL) for transport through the blood to tissues that require them. Phosphatidylcholine is a required component of VLDL particles. Without adequate phosphatidylcholine, fat and cholesterol accumulate in the liver (see Deficiency).
Choline Linus Pauling Institute
http://lpi.oregonstate.edu/infocenter/othernuts/choline/
Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/
CFS-me-as-a-liver-issue
http://forums.phoenixrising.me/index.php?threads/cfs-me-as-a-liver-issue.18776/
Radio: Is there a silent liver disease connection?
Nonalcoholic steatohepatitis or NASH is a common, often “silent” liver disease. It resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. The major feature in NASH is fat in the liver, along with inflammation and damage. Most people with NASH feel well and are not aware that they have a liver problem. Nevertheless, NASH can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly.
See more at :
The Silent liver disease.
http://digestive.niddk.nih.gov/ddiseases/pubs/nash/
Radio: A bacterial overgrowth can also produce histamine, hydrogen sulfide, hydrogen peroxide, tryptophanase, d-lactic acid and endotoxins. This could be a possible contributing factor to the acquired mitochondrial disease and silent organ damage.
Fatty liver
http://en.wikipedia.org/wiki/Fatty_liver
Non-alcoholic Fatty Liver Disease
http://en.wikipedia.org/wiki/Non-alcoholic_fatty_liver_disease
Downregulation of Hepatic Glucose-6-Phosphatase-α in Patients With Hepatic Steatosis
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.118/full
Detoxification (The Liver)
http://www.gilbertssyndrome.com/detoxification.php
How-I-Recovered-From-CFS-part 2
http://forums.phoenixrising.me/index.php?threads/how-i-recovered-from-cfs-part-2.28684/
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