Lipid replacement therapy can potentially help everyone in this forum. It does not matter which subgroup of CFS/ME you are in. The core of the problem has always been acquired mitochondrial damage. Repairing the Mitochondrial is the first step in healing.This is one of the missing links in the chain to recovery. At this point, the fact is, we need Mitochondrial support. The Mitochondria can becomes damaged and leaky from an overload of metabolic waste. Phospholipids and glycolipids can repair cellular membranes by increasing cell membrane fluidity. By repairing these membranes we allow our cells to increase their nutrient uptake so that the mitochondria may product more ATP. Acquired mitochondrial damage is a normal part of aging, but is accelerated in chronic fatigue syndrome and many other metabolic disorders. We must address this before complete healing can be initiated. Phospholipids replacement therapy and eating a super clean diet is the first critical steps in repairing this damage. Chronic deficiencies and Methylation imbalance destroys the mitochondrial membranes and lead to the modern day diseases we see today. How I Heal My Mitochondria, (Simplified Recovery Protocol) 1. Super clean diet (The low histamine Chef Diet + Organic rice) No coffee, No table salt (Just Eat Real Food). 2. High dose Phospholipid therapy, NT Factor powder or Smart Youthful Energy Wafers 2-4xday Look for link at the bottom of this page. BodyBio PC is another supplement to consider if you have the money. Digestive supplementation is recommended to increase the absorption of the phospholipids. 3. Mineral Deficiencies Support, Pure encapsulations Mineral 650 or Pure encapsulations Trace Mineral 1xday...look for link at bottom of this page. 4. Low Dose Methylation Support, Fred's B12 Methylation Protocol <---(last step), Also, Limit P5P (pyridoxal-5-phosphate) inhibits PST (phenol sulphur-transferase) activity. P5P is not water soluble and can build up in the body damaging the peripheral nervous system. I have discovered that if I focused on supporting the mitochondria first, I was able to tolerate the B12 protocol with out triggering the potassium depletion. Also, my cells needed less active B vitamins because absorption into the cell was increased dramatically. By repairing the mitochondria first, we allow our cells to increase their nutrient uptake so that methylation support will have the most dramatic effect. Lipid replacement therapy is a critical step in balancing methylation without over-driving this metabolism. NT Factor does not contain any soy proteins, the source of soy antigens that cause allergic reactions.The phospholipids extracted from soy are exactly the same phospholipids that are in your cell membranes of every cell in your body. The advantage of NT Factor over foods ( Soy ) that contain lipids is that NT Factor lipids are protected from oxidative damage during storage, digestion and intake into your body. Food lipids are not protected, and you are taking in oxidative-damaged lipids as well as natural lipids. Lipid Replacement Therapy Lipid replacement therapy (LRT) has been used along with other strategies, such as antioxidant therapy, to replace damaged or oxidized cellular lipids that accumulate during aging and in various clinical conditions. Differing from traditional lipid nutritional supplementation, LTR replacement lipids are protected from oxidation and damage during storage, ingestion and digestion. Important lipids that require constant replacement are phospholipids, glycophospholipids and other lipids that make up cellular and organelle membranes, especially mitochondrial membranes. Decreased mitochondrial function and loss in the efficiency of the electron transport chain are related to aging and fatigue. Oxidative damage to mitochondria, mainly from Reactive Oxygen Species (ROS), results in peroxidation of cellular and mitochondrial lipids, proteins and DNA, but it is ROS damage to mitochondrial membrane lipids that may cause the most rapid loss of mitochondrial function. LRT along with antioxidants can circumvent ROS membrane damage and replace and restore mitochondrial and other cellular membrane functions via delivery of replacement lipids in their unoxidized, undamaged states. Recent clinical trials have shown the benefit of LRT plus antioxidants in restoring mitochondrial electron transport function and reducing fatigue. Look for the NT factor with phospholipids (only) with "NO" add supplements. It has to be just plan NT Factor. NT Factor Proprietary Lipid Blend 12,00mg Phosphatidic acid (PA) Phosphatidyl-choline (PC) Phosphatidyl-ethanolamine (PE) Phosphatidyl-glycerol(PG) Phosphatidyl-inositol (PI) Phosphatidyl-serine (PS) Digalactosyldiacylglyceride (DGDG) Monoglactosyldiacylglyceride (MGDG) Nicolson 2014 - Use of Natural Supplements to Improve Mitochondrial Function (CFS) Full paper available here: http://functionalfoodscenter.net/files/81845995.pdf CFS - The Central Cause: Mitochondrial Failure http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure BodyBio PC E-Lyte's BodyBio PC is a concentrated Phosphatidyl Choline/Lecithin product. It is available in liquid or capsule form. Clearly with the liquid then although you need to measure it up, there is no capsule consumption each time. Each capsule contains 900mg of 'phospholipid complex'. Of this 900mg of phospholipid complex, approximately 450-605mg is Phosphatidyl Choline, according to the manufacturer's UK distributor, although this fact is not stated on the product packaging. According to this source, the average content of Phosphatidyl Choline per capsule is 528mg, with and a smaller amount of Phosphatidyl Ethanolamine and Phosphatidyl Inositol and minor glycolipids. If this is indeed correct, then it would make it the most concentrated source of Phosphatidyl Choline capsule on the market, at 58%. The quoted phospholipid content is quoted at 66%. BodyBio PC also contains a 4:1 ratio of Linoleic Acid (LA - Omega 6) and Alpha-Linolenic Acid (ALA - Omega 3) Essential Fatty Acids (EFA), but it is not known what the exact ratio of Lecithin concentrate to EFAs that make up the 900mg of 'Phospholipid Compex'. The ingredients state that the total fat content is 900mg, of which the saturated fat content is 200mg, the polynunsaturated fat content is 600mg and the monounsaturated fat content is 110mg. As the ingredients do not specify the exact amounts of each, and polyunsaturates describes both the Phospholipids (propotion of the Lecithin) and the Essential Fatty Acids, then it is not very helpful (presumably for anti-competitive reasons). However, the figures cannot be quite correct as the ingredients are listed as being solely fat, yet the total calories per capsule is 9 (of which 8 come from fat - the other 9% coming from carbohydrates - which are not listed on the ingredients). BodyBio PC is also available in liquid form, where 1 tsp (teaspoon) contains 1500-1800mg of Phosphatidyl Choline. The target daily dosage of Body Bio PC capsules is 4 capsules twice a day (or 3 capsules three times a day - which is slightly more), providing between 3.6 - 4.85g of Phosphatidyl Choline. You may wish to increase the dosage over time, but this is best done with advice from your medical practitioner. Some people, including myself, have found at certain points in time that taking 4 capsules 3 times a day (i.e. a total of 12, providing between 5.4 - 7.25g of Phosphatidyl Choline) is a comfortable upper limit (after a few months at 8 capsules a day). This clearly depends on the individual however. Indeed at other times, a much reduced limit was tolerated, depending on general liver health and glucuonidation pathway efficiency in the liver. The integrity of mitochondrial membranes is critical to cell function and energy metabolism. This membrane is the frontier between cell survival and death. Lipid Replacement Therapy®, Fatigue and Dysbiosis – the Mitochondrial and Immune Connection http://www.nleducation.co.uk/resour...osis-the-mitochondrial-and-immune-connection/ Lipid Replacement Therapy with a Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients http://www.scirp.org/journal/PaperInformation.aspx?paperID=19382#.UvwAGbRYw-8 A Modern Approach to the Treatment of Mitochondrial Disease http://www.epidemicanswers.org/wp-content/uploads/2010/05/Modern-Approach-to-Treatment-of-Mito.pdf Supplements BodyBio PC http://www.amazon.com/dp/B001169CF6...=UTF8&colid=STE6K5DNMJYK&coliid=IJ444PD8I5XBI Now foods super enzymes http://www.iherb.com/search?sug=now foods super enzymes&kw=now foods su&rank=4#p=1 NT Factor (Nutri cology Nt factor) http://www.iherb.com/Nutricology-NT-Factor-EnergyLipids-Powder-150-grams/45698#p=1&oos=1&disc=0&lc=en-US&w=NT Factor (Nutri cology Nt factor)&rc=12&sr=null&ic=3 Smart Youthful Energy Wafers www.amazon.com/Energy-Chewable-Wafers-Factor-Lipids/dp/B00DMINPRM Pure encapsulations Mineral 650 1xday or Pure encapsulations Trace Mineral 1xday http://www.iherb.com/Pure-Encapsula...apsulations Trace Mineral&rc=238&sr=null&ic= Life Extension, Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support, 50 mg, 2xday http://www.iherb.com/Life-Extension-Super-Ubiquinol-CoQ10-with-Enhanced-Mitochondrial-Support-50-mg-100-Softgels/22796#p=1&oos=1&disc=0&lc=en-US&w=Super Ubiquinol Coq-10 W Enhanced Mitochondrial&rc=8&sr=null&ic=1 Disclaimer, The information in this thread is not intended to be medical advice. The information is meant to inspire and motivate you to make your own decisions surrounding your health care and dietary needs. It is intended for educational and informational purposes only. You should not rely upon any information found on this thread to determine dietary changes, a medical diagnosis or course of treatment. Readers should perform their own research and make decisions in partnership with their own health care providers. Any statements or claims about the possible health benefits obtained from any foods or supplements mentioned on this thread have not been evaluated by the Food & Drug Administration and are not intended to diagnose, treat, cure or prevent any disease. The Recovery Protocol in the thread is not acting in the capacity of a doctor, licensed dietician, licensed nutritionist, psychologist or other licensed or registered professional. This thread is for educational purposes only to document that recovery is possible.