So my theory is that pple with CFS/ME actually have a problem with their liver function. From all the liver tests that I have done and all the other pple with cfs that I have interviewed and looked at their lab work, the common result is that phase 1 is very out of whack with phase 2. Phase 1 can be function at like 20 times faster than phase 2 causing all these intermediate metabolites to spill over into the blood and go everywhere else in the body to cause havoc. Slowing down and speeding up phase 2 seems to be the most practical thing to do but even then it is not easily accomplished since the liver phase one is working at a much faster pace than phase 2 there is no realistic way of speeding up phase 2 and all it's 6 detox pathways at once. I think that a better way to do this is to stabilise the liver and make it work more orderly and this should help much more. All these toxins running around is what is causing problems with the other glands, organs and the gut. If you do not treat the liver with whatever system you are treating at the same time, the issue with only come back. The solution is: a good multiple B vitamin complex and Grapefruit juice. You can take the B complex a few times a day even and drink 4-5 cups of grapefruit juice. The B vitamins taken together with stabilise the liver and make it work more normally which grapefuit can slow dwn phase 1. Citrus fruits, which grapefruit is a member if is very very interesting. In all my research that I have done, they either speed up phase 2 or slow down phase 1. Both these 2 effects are desired when you have cfs. Of all the citrus fruits I have read, only grapefruit and bergamote, slow dwn phase 1, the rest speed up phase 2. Also it is not just the juice or the pulp that you have to eat, it is the whole fruit. Much of the active ingredients are in the rind/peel and whites of the fruit. When you juice, put the whole fruit in. Again just taking these citrus fruits alone is not enough because phase 1 is so quik that that the whole detox system is out of whack. There is no way you can make phase 2 keep up, you need to slow phase 1 dwn. Grapefruit and B vitamins do that.