In Rich's explanation he mentioned 3 groups. It's not just about you. For those in the first group, glutathione will actually protect B12. It's true that Rich's explanation regarding you is theoretical. We don't know why this happens to some people, but it doesn't happen to everyone. I agree that NAC and glutathione probably aren't the best ways to raise glutathione even if they don't remove B12 from an individual's body. We don't know how prevalent this is so maybe you're right that to be on the safe side everyone should avoid NAC and glutathione. I just wanted to point out that it doesn't happen to everyone. What you say about this and what Rich say are both theoretical and we really don't know exactly what's going on or how prevalent it is. Glutathione, NAC, and non-denatured whey were used for a period of time because they seemed to be helping a significant number of individuals. Although Rich and Dr. Cheney among many others discarded the treatment eventually since it seemed to only provide a temporary benefit, enough people didn't have an adverse reaction or the treatment would have been discontinued immediately. That said, raising glutathione is very important and it would be a mistake for anyone reading this to assume that glutathione in general is bad. It's seems raising glutathione via NAC, L-Cysteine, L-Glutathione, and non-denatured whey could have deleterious effects on some individuals. However, improving mitochondrial function and getting the Krebs Cycle going will also raise glutathione and many of the supplements in your protocol do just that. When glutathione is depleted that causes B12 to become depleted. And as I mentioned before one of the main purposes of methylation is to raise glutathione. Some of the people here seem to be confused about glutathione so this stuff needs to be made clear.