Hi all. Like a lot of you I've been struggling with various mental and physical issues for a long time, and after much reading on this site and others I decided to use 23&me to identify my SNPs. Hopefully this will help me decide on a successful course of action instead of fumbling around in the dark. I know only a little about methylation, but right away I saw that I was +/- at MTHFR C677T. Not terrible news, but likely indicating a compromised methylation pathway. As you can see I'm +/- VDR Bsm & Taq and at two of the CBS genes, as well. Also +/+ at three of the four BHMT genes is troubling. As of now I'm considering beginning a protocol of subliminal methylcobalamin followed shortly by metafolin. I'm also going to get my blood tested for homocysteine to get a baseline number. If anyone has anything pertinent to add I'd greatly appreciate it!