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My Methylation SNPs - your help greatly appreciated!

Discussion in 'Genetic Testing and SNPs' started by xjhuez, Feb 21, 2013.

  1. xjhuez

    xjhuez Senior Member

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    Hi all.

    Like a lot of you I've been struggling with various mental and physical issues for a long time, and after much reading on this site and others I decided to use 23&me to identify my SNPs. Hopefully this will help me decide on a successful course of action instead of fumbling around in the dark.

    I know only a little about methylation, but right away I saw that I was +/- at MTHFR C677T. Not terrible news, but likely indicating a compromised methylation pathway.

    As you can see I'm +/- VDR Bsm & Taq and at two of the CBS genes, as well.

    Also +/+ at three of the four BHMT genes is troubling.

    As of now I'm considering beginning a protocol of subliminal methylcobalamin followed shortly by metafolin. I'm also going to get my blood tested for homocysteine to get a baseline number.

    If anyone has anything pertinent to add I'd greatly appreciate it!


    MethylationAnalysis.png
     
  2. caledonia

    caledonia

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    If you have any problems tolerating the methyl donors (mB12 and mfolate), such as an stress/anxiety response, then CBS is likely expressed. You'll have to go back and address that first.

    Heartfixer has a good summary of what to do about CBS. http://www.heartfixer.com/AMRI-Nutrigenomics.htm
     
  3. LaurieL

    LaurieL Senior Member

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    Hi there! Could you please expand on these issues a bit for us?

    Lauriel
     
  4. xjhuez

    xjhuez Senior Member

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    Hi caledonia,

    I took 1000mcg sub-lingual mB12 yesterday and I felt pretty good. Nothing magical, but definitely no negative reaction. I might ramp it up either the dose or the frequency if the next few days go well.

    No mfolate yet - I found Solgar's Metafolin here locally but unfortunately it contains mannitol, and mannitol and I don't get along very well.

    Thanks for the heartfixer link. Great info, but confusing on first read. I guess less confusing and just a lot to digest.
     
  5. xjhuez

    xjhuez Senior Member

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    Hi Lauriel,

    Physical issues - General low energy and I fatigue easily. I refuse to give in to whatever's wrong with me and be sedentary, and I've found that I do better on HITT type routines, as anything that requires my body to sustain energy output over time (running, treadmill) is too difficult.

    I took up lifting weights and discovered that, despite working out and eating right, I have a hard time building muscle. Also, when I stop lifting I incur rapid muscle catabolism. I've always been thin with a "fast" metabolism, but it's odd the way my body takes me back to skin n bones as fast as it can. Seems like an endocrine issue - possibly low test or high cortisol (or both).

    I have hypoglycemia that I control via diet.

    As far as mental issues.. I have a laundry list. Avolition, social withdrawal, anxiety, mild OCD, etc.

    I have excitotoxicity issues with glutamate/NMDA. I definitely know when I've eaten something containing MSG. I had to stop taking protein powder because it contains too much free glutamate.

    Insomnia. I fall asleep just fine, but suffer from multiple awakenings during the night. Anything and everything wakes me up, and I very rarely wake feeling rested.
     
  6. caledonia

    caledonia

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    It took a few days for the mB12 to hit me.
     
  7. xjhuez

    xjhuez Senior Member

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    Several days in on the sub-lingual mb12 and feeling pretty good, no issues yet.

    What should I expect if/when it hits me?

    Also after further reading on Freddd's protocol I'm wondering if Dibencoplex would help my muscle issues.

    Also, I noticed that NAC is discouraged because it turns mb12 into "glutathionylb12" which is bad. Hmm. I've been using NAC to raise glutathione..

    Also apparently I should take potassium.
     
  8. caledonia

    caledonia

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    I got an stress/anxiety response.
     
  9. xjhuez

    xjhuez Senior Member

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    So far so good with mb12. Morning urine is pinkish, so it's not all being used, but I guess this is normal. Introducing mfolate next week.

    Updated this image after reading genetic gene and heartfixer. Will probably need to read them again - info overload.

    MethylationAnalysis2.png
     

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