after trying almost everything from the roadmap, I decided that I should pursue the last treatment I've not pursued - Daratumumab. I already found a doctor available to prescribe it, but I don't think he will follow my case. I'm looking for CFS trials with the drug, but couldn't find any information about doses and frequency.
What should I know before pursuing Daratumumab?
- Thread starter glazevedx
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cfs since 1998
Senior Member
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Might want to read:
"Is There a Future for Anti-CD38 Antibody Therapy in Systemic Autoimmune Diseases?"
Unfortunately, no discussion of dosage, but interesting information nonetheless.
One drawback: "CD38 is also widely expressed by IL-10 producing regulatory B cells [67]. Therefore, it could be argued that the depletion of immunosuppressive and regulatory subtypes may limit the efficacy of anti-CD38 therapies, or, in worst cases, induce a flare of the autoimmune disease."
"Is There a Future for Anti-CD38 Antibody Therapy in Systemic Autoimmune Diseases?"
Unfortunately, no discussion of dosage, but interesting information nonetheless.
One drawback: "CD38 is also widely expressed by IL-10 producing regulatory B cells [67]. Therefore, it could be argued that the depletion of immunosuppressive and regulatory subtypes may limit the efficacy of anti-CD38 therapies, or, in worst cases, induce a flare of the autoimmune disease."
cfs since 1998
Senior Member
- Messages
- 879
I tried roflumilast, which gave me insane RLS and agitation. I met just a few people as refractory to trataments as me. 7 years trying drugs and nothing that really worked.