What should i expect from these supplements?

[wasted_potential]

After reading various posts about the benefits of different supplements i decided to order some and see if they would make any difference for my various symptoms. Im mainly looking for anxiety (wired but tired) and brain fog relief. I have tried all of them and have to say i havent noticed any benefits so far.
My question is then, when should i expect to notice any benefits from these supplements? And what doses should i optionally try?

• NAC (N-Acetylcysteine) I have been taking this for a month. I havent noticed much at 1000mg twice daily.
  
  
• NAG (N-acetyl-glucosamine) Have been taking this the last few days at 700mg twice daily. Havent noticed any benefit so far.
  
  
• Turmeric This alongside NAG and flaxceed oil was supposed to treat anxiety. I have taken this a couple of days now and havent noticed any benefit/effect. Might need to take it longer idk.
  
  
• D-Ribose I have only taken this a couple of times at normal dose and havent noticed anything.
  
  
• QoC10 I have been taking this at 400mg a day and havent noticed any improvement in symptoms.
  
  
• Flaxceed oil Only taken one time and didnt notice anything.
  
  
• DHEA Only taken one time and didnt notice anything.
  
  
• PQQ This was supposed to increase energy. I havent noticed anything so far.
  
  
• L-Theanine Ive taken this on a couple of occasions at 200mg. Have noticed slight relaxation and calming of the mind. This is probably the only supplement that has shown any benefit.
  
  
• Bacopa Ive only tried this once and it made me feel worse with more brain fog.
  

 

[drob31]

I would recommend trying Creatine.

 

[pamojja]

After reading various posts about the benefits of different supplements i decided to order some and see if they would make any difference for my various symptoms.

In my opinion nutrients and herbs are most of the time very different from drugs, in that their strength only comes apparent over long time intakes. One way to know beforehand would be to do extensive lab testing to see some effects before and after firsthand.

For example NAC and others (the more so in synergy) might increase glutathione, which could be tested directly or indirectly with other oxidative blood markers (oxLDL, ..) . Semi essential nutrients like CoQ10 or DHEAs can be tested directly if deficient. Fatsolubles like CoQ10 and Omega3 from flaxseed take many month to raise it in tissues. Etc. Bacopa makes me tired too, therefore use it only before sleep to improve it.

In my 10 years experience of using comprehensive supplementation I could reverse a 60% walking-disability from PAD after 6 years (of which I was told that there isn't a way to reverse, but only merciless progression). However, could hardly pin this improvement down to a single supplement - but to the synergistic improvement of all body systems. As seen in liver and kidney function, hormone and nutrient panels, lipids and glucose metabolism, CBC, bood pressure, etc. all together.

Then there are side-benefits from synergistic supplementation I haven't even heard of. For example don't get any sunburns anymore probably from all the anti-oxidants. But don't ask me which one

If I only supplemented those where one 'feels' something immediately - which is rather very rare - I don't think I wouldn't have gotten such multifaceted benefits.

 

[Sundancer]

• Turmeric This alongside NAG and flaxceed oil was supposed to treat anxiety. I have taken this a couple of days now and havent noticed any benefit/effect. Might need to take it longer idk.

• QoC10 I have been taking this at 400mg a day and havent noticed any improvement in symptoms.

• Flaxceed oil Only taken one time and didnt notice anything.

• L-Theanine Ive taken this on a couple of occasions at 200mg. Have noticed slight relaxation and calming of the mind. This is probably the only supplement that has shown any benefit.

turmeric seems to help my immunesystem, been using it now for 8 month, I think it helps taking care of sickness in the night, this has lessened.

QoC10 made me ill

Flaxseedoil I've used some months and then stopped, I think I get unwanted effects from it

theanine I've been using for more then 2 years now and I will keep taking it. It calms down the glutamate route and helps the dopaminesystem getting back in balance. But that tales time, lots of time.

agree with @pamojja , I take more stuff, and these things work together and over a long time.

 

[LINE]

I always start with the baseline nutrients (minerals, vitamin co-factors,anti oxidants), these are the ones that are foundational for the body's multiple needs. Anxiety is a lack of GABA in the brain and can be traced to excessive glutamate. Glutamate is a neurotransmitter but is excitatory meaning too much creates anxiety and stimulation. GABA has the opposite effect. Most of the prescription drugs for anxiety work by keeping GABA in the synapse, rather than actually creating it.

GABA formation comes from baseline nutrients such as magnesium. Low magnesium shows up in any stress disorder, which ME would be one. Stress includes biological stress, not just emotional stress. Biological stress would include infections and toxins. Anytime you evoke stress then nutrient levels will fall. B vitamins play a key role in health and should not be overlooked, it is better to use the full spectrum rather than taking individuals, say B12. Solaray makes a nice balanced b complex (Solaray Nutritionally Balanced B-Stress).

My anxiety was fixed using GABA Calm by Source Naturals and the baseline nutrients. Wired and tired is a sign of low energy.

Vitamin and nutrient reference http://lpi.oregonstate.edu/mic/vitamins

I agree with the other posters about the role of turmeric, it has been very helpful. I buy it in bulk and organic. Make sure you take adequate amounts.

 

[mattie]

when should i expect to notice any benefits from these supplements? And what doses should i optionally try?

I took all of those supplements and many more.
Never ever had the tiniest benefit from any supplement.

 

[wasted_potential]

I always start with the baseline nutrients (minerals, vitamin co-factors,anti oxidants), these are the ones that are foundational for the body's multiple needs. Anxiety is a lack of GABA in the brain and can be traced to excessive glutamate. Glutamate is a neurotransmitter but is excitatory meaning too much creates anxiety and stimulation. GABA has the opposite effect. Most of the prescription drugs for anxiety work by keeping GABA in the synapse, rather than actually creating it.

GABA formation comes from baseline nutrients such as magnesium. Low magnesium shows up in any stress disorder, which ME would be one. Stress includes biological stress, not just emotional stress. Biological stress would include infections and toxins. Anytime you evoke stress then nutrient levels will fall. B vitamins play a key role in health and should not be overlooked, it is better to use the full spectrum rather than taking individuals, say B12. Solaray makes a nice balanced b complex (Solaray Nutritionally Balanced B-Stress).

My anxiety was fixed using GABA Calm by Source Naturals and the baseline nutrients. Wired and tired is a sign of low energy.

Vitamin and nutrient reference http://lpi.oregonstate.edu/mic/vitamins

I agree with the other posters about the role of turmeric, it has been very helpful. I buy it in bulk and organic. Make sure you take adequate amounts.

Thank you for the response. How much Turmeric do u take? Currently i take 1000mg once a day.

 

[wasted_potential]

turmeric seems to help my immunesystem, been using it now for 8 month, I think it helps taking care of sickness in the night, this has lessened.

QoC10 made me ill

Flaxseedoil I've used some months and then stopped, I think I get unwanted effects from it

theanine I've been using for more then 2 years now and I will keep taking it. It calms down the glutamate route and helps the dopaminesystem getting back in balance. But that tales time, lots of time.

agree with @pamojja , I take more stuff, and these things work together and over a long time.

How much turmeric and theanine do u take in a day?

 

[wasted_potential]

Thanks for the response.

 

[Wishful]

The correct answer to your question is: 'You'll have to try them yourselves to find out'. We all seem to respond differently to things such as supplements. One person will have a positive effect, another a negative effect, most will probably notice no effect. The 'proper' amounts vary too: one will have an optimum level of 5 mg while another requires 1500 mg. Some will notice an effect in hours; another won't notice an effect for weeks. It does make testing difficult. When do you give up on an experiment? It's up to you.

My experience is opposite to pamojja's: the things that have an effect (positive or negative) on my ME typically have an effect within 24 hrs. I haven't found anything that had a gradual improvement over days or longer. Prednisone took 5 days to have an abrupt improvement the first time; 2 days the second time...then never worked again.

Of the supplements you listed that I've tried, none had a positive effect, and turmeric has a strong negative effect.

I consider it worthwhile to test some supplements and drugs, since there's at least a chance one or more might help, and some might give a negative effect and tell what you need to avoid. However, I think the honest answer to your question is: 'You should expect no noticeable effect from most supplements'. Sad, but true. There probably are a few treasures (things that actually help you) somewhere in the world. I've found two in 17 years, and I found them by accident. Okay, only one is a supplement (T2). The other is a spice (cumin). I think the chances of finding a useful herb or spice is better than finding a useful supplement. We should get enough of the essentials from a decent diet; any excess is most likely just wasted.