Hi sorry I am relatively new here, and just beginning to learn a few things. What do you mean by needed cofactors and how do you take mb12 adb12?!
Here is the preliminary information you need. Then join one of the conversations that strikes your fancy from your more specific questions on the methylation menu from which that originates and tell us about your symptoms and so on. There is a list of about 300 symptoms in several places that has every FMS/CFS symptom and way more that the active b12 protocl can help. I am long cured of FMS/CFS.