percyval577
nucleus caudatus et al
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Because ME/CFS triggering viruses either have an effect on the vitamin D receptor or can be associated with vitamin D (thread and lit.) it should be wise to have a look at deficiencies (although a simple relationship is hardly to be expected).
Vitamin D status in chronic fatique syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England
Earl et al 2017
from the Discussion (my paragraphing)
from the Discussion
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Vitamin D status in chronic fatique syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England
Earl et al 2017
from the Discussion (my paragraphing)
In conclusion, patients with CFS/ME do not exhibit insufficient concentrations of circulating 25(OH)D3 at any time of the year. Given that this cohort of patients with CFS/ME clearly displays symptoms, regardless of serum 25(OH)D concentration, these data indicate that vitamin D status may not be a major contributing factor to the pathophysiology of patient with CFS/ME symptoms, although further analyses of those individuals with lower circulating 25(OH)D and more detailed investigation into vitamin D metabolism is still warranted.
Current health guidelines in the UK state supplementation of vitamin D should be recommended to individuals with increased risk of deficiency and the findings from the present study suggest, in agreement with other studies, that a significant percentage of healthy individuals exhibit insufficient concentrations of circulating vitamin D during the autumn and winter months.
The current findings do not support the notion that vitamin D concentration contributes to the continuing symptoms of CFS/ME. However, it may be important for patients with CFS/ME to supplement with vitamin D during the winter months as it is well documented that non-supplemented individuals may typically present with insufficient serum 25(OH)D during the winter season.
from the Discussion
A further limitation to the study was that only the main marker of vitamin D status, that is, 25(OH)D, was measured. It has recently been shown that there is a need to assess all of the vitamin D metabolites.35 [Johnson et al 2014: "Serum free and bioavailable 25-hydroxyvitamin D correlate better with bone densitiy than serum total 25-hydroxyvitamn-D.] It may be more appropriate to measure the amount of serum-free and bioavailable 25(OH)D as a predictor of vitamin D status than serum total 25(OH)D, while controlling for vitamin D binding protein phenotype.36 Future studies assessing these aspects of vitamin D metabolism in patients with CFS/ME are warranted.
open access
BMJ Open. 2017 Nov 8;7(11):e015296. doi: 10.1136/bmjopen-2016-015296.
BMJ Open. 2017 Nov 8;7(11):e015296. doi: 10.1136/bmjopen-2016-015296.
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