VDR gene polymosphisms: allelic interpretation

[nanonug]

According to the paper ("Molecular Epidemiology of Vitamin D Receptor Gene Variants"):

• FokI - C allele corresponds to F; T allele corresponds to f; C is risk allele; and,
• BsmI - B allele strong concordance with TaqI t allele; bb genotype frequency is 2% Asians and 17% Caucasians. Looking at dbSNP for rs1544410 this suggests that B=G and b=A.

Is this interpretation of FokI and BsmI/TaqI alleles correct?

PS: I still don't understand the significance assigned by Yasko to these polymorphisms...

 

[determined]

I wish there were more information about these and many other SNPs. The ability to detect them is way ahead of an understanding of what they might mean.

 

[triffid113]

idk, I have both of them. For the one that affects ability to retain vitamin D and thus absorb calcium, I take 50,000 units D/week sublingual from Superior Source from iherb (I buy the 5,000 unit bottle). I maintain my D levels in blood at 70 and this is ideal. Correct D levels are required for correctly regulating one of the methylation enzymes.

The other VDR defect has something to do with diabetes? I don't recall. So far I am beating diabetes with DHEA (diabetes is tied to low testosterone in men, ok I am a woman but DHEA also makes estrogen - whatever, it seems to work). I also take OLE to protect the cells of the pancreas from something that destroys them according to some study reported at www.lef.org. I actually take OLE for other reasons, this is just a bonus.

The above seems to do the trick for both VDR defects as far as I can tell...

Trif